4-nitrophenyl-[(2S)-4-(3,4-difluorobenzyl)morpholin-2-yl]methylcarbamate | 610799-38-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrophenyl-[(2S)-4-(3,4-difluorobenzyl)morpholin-2-yl]methylcarbamate
• 英文别名: (4-nitrophenyl) N-[[(2S)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methyl]carbamate
• CAS: 610799-38-7
• 化学式: C₁₉H₁₉F₂N₃O₅
• 分子量: 407.374
• InChiKey: VRDRRTFXLFZVKP-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  96.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1487455A1

  公开（公告）日：2004-12-22
• [EN] MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS<br/>[FR] DERIVES DE MORPHOLINE SUBSTITUES AU NIVEAU DE LA POSITION 2 PAR UN GROUPE ARYLALKYLUREE UTILISE EN TANT QU'ANTAGONISTES DE CCR-3 DANS LE TRAITEMENT D'ETATS INFLAMMATOIRES
  申请人：GLAXO GROUP LTD

  公开号：WO2003082292A1

  公开（公告）日：2003-10-09

  Certain compounds of formula (I); wherein R1 represents unsubstituted or substituted aryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6 alkyl; n is an integer from 1 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6 alkyl; and salts and solvates thereof are CCR3-antagonists and are thus indicated to be useful in therapy of inflammatory conditions.