4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-[3-(1-methyl-1H-pyrazole-4-sulfonylamino)-propoxy]-benzamide | 1084332-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-[3-(1-methyl-1H-pyrazole-4-sulfonylamino)-propoxy]-benzamide
• 英文别名: 4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-[(1-methylpyrazol-4-yl)sulfonylamino]propoxy]benzamide
• CAS: 1084332-66-0
• 化学式: C₂₀H₂₀F₂IN₅O₄S
• 分子量: 591.377
• InChiKey: UZKPCPUPBNHWGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity
  申请人：Li Yingfu

  公开号：US20090082328A1

  公开（公告）日：2009-03-26

  This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

  本发明涉及新颖的取代苯基氨基苯化合物、含有这些化合物的药物组合物以及将这些化合物或组合物作为唯一活性成分或与其他活性成分联合使用治疗增生和/或血管生成异常的用途。
• SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY
  申请人：Rudolph Joachim

  公开号：US20110071125A1

  公开（公告）日：2011-03-24

  This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

  本发明涉及新型取代苯胺基苯化合物、含有这种化合物的制药组合物以及将这些化合物或组合物用于治疗增殖过度和/或血管生成障碍，作为单一药物或与其他活性成分联合使用的用途。
• SUBSTITUTED PHENOXYBENZAMIDES
  申请人：Hitchcock Marion

  公开号：US20110039819A1

  公开（公告）日：2011-02-17

  The present invention relates to substituted phenoxybenzamide compounds of general formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 , X, R 6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式(I)的取代苯氧基苯甲酰胺化合物，其中R1、R2、R3、R4、R5、X、R6和q在权利要求中定义，以及制备该化合物的方法、包含该化合物的药物组合物和制造用于治疗或预防疾病，特别是高增殖和/或血管生成紊乱的药物组合物的药用化合物的用途，作为唯一药剂或与其他活性成分组合使用。
• SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2155659A1

  公开（公告）日：2010-02-24
• [EN] SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY<br/>[FR] DÉRIVÉS DE PHÉNYLAMINO-BENZÈNE SUBSTITUÉS UTILES POUR LE TRAITEMENT DE MALADIES ET DE TROUBLES HYPERPROLIFÉRATIFS ASSOCIÉS AVEC L'ACTIVITÉ DES KINASES EXTRACELLULAIRES ACTIVÉES PAR DES MITOGÈNES
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2008138639A1

  公开（公告）日：2008-11-20

  [EN] This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
  [FR] L'invention concerne de nouveaux composés de phénylamino-benzène substitués, des compositions pharmaceutiques qui contiennent de tels composés et l'utilisation de ces composés ou de ces compositions pour le traitement de troubles hyperprolifératifs et/ou de l'angiogenèse, en tant qu'agent unique ou en combinaison avec d'autres ingrédients actifs.