6-Amino-9H-purin-9-acetamid | 98277-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-Amino-9H-purin-9-acetamid
• 英文别名: 2-(6-amino-purin-9-yl)-acetamide；Acetamide, 9H-(adenin-9-yl)-；2-(6-aminopurin-9-yl)acetamide
• CAS: 98277-56-6
• 化学式: C₇H₈N₆O
• 分子量: 192.18
• InChiKey: RVZMUNXBWYWNJA-UHFFFAOYSA-N

物化性质

• 沸点：
  573.6±60.0 °C(Predicted)
• 密度：
  1.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Osmiumtetroxide-based conversion of RNA and DNA containing thiolated nucleotides
  申请人：UNIVERSITY OF INNSBRUCK

  公开号：US11254982B2

  公开（公告）日：2022-02-22

  Provided are compositions and methods for the conversion of thiolated nucleotides, and subsequent detection of the converted nucleotides in RNA or DNA. Also provided herein are compositions and methods for the metabolic labeling of RNA and DNA by incorporation of thiolated nucleotides, and their subsequent conversion and detection.

  本文提供了硫醇化核苷酸转化以及随后检测 RNA 或 DNA 中转化核苷酸的组合物和方法。本文还提供了通过掺入硫代核苷酸对 RNA 和 DNA 进行代谢标记以及随后对其进行转化和检测的组合物和方法。
• SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUCLEIC ACID MOLECULES FOR GENOMIC AND THERAPEUTIC APPLICATIONS
  申请人：RedVault Biosciences LP

  公开号：EP3129505A1

  公开（公告）日：2017-02-15
• OSMIUMTETROXIDE-BASED CONVERSION OF RNA AND DNA CONTAINING THIOLATED NUCLEOTIDES
  申请人：UNIVERSITY OF INNSBRUCK

  公开号：US20200048700A1

  公开（公告）日：2020-02-13

  Provided are compositions and methods for the conversion of thiolated nucleotides, and subsequent detection of the converted nucleotides in RNA or DNA. Also provided herein are compositions and methods for the metabolic labeling of RNA and DNA by incorporation of thiolated nucleotides, and their subsequent conversion and detection.
• DNA-BARCODED ANTIGEN MULTIMERS AND METHODS OF USE THEREOF
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US20210139985A1

  公开（公告）日：2021-05-13

  Provided herein are methods compositions and methods to generate pMHC libraries, and methods of using the pMHC libraries to determine the sequences of T cell receptors, and T cell developmental and activation status.
• [EN] SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUCLEIC ACID MOLECULES FOR GENOMIC AND THERAPEUTIC APPLICATIONS<br/>[FR] SYSTEMES ET PROCEDES DE REPLICATION CLONALE ET D'AMPLIFICATION DE MOLECULES D'ACIDE NUCLEIQUE POUR DES APPLICATIONS GENOMIQUES ET THERAPEUTIQUES
  申请人：REDVAULT BIOSCIENCES LP

  公开号：WO2015157747A1

  公开（公告）日：2015-10-15

  The present invention provides for methods, reagents, apparatuses, and systems for the replication or amplification of nucleic acid molecules from biological samples. In one embodiment of the invention, the nucleic molecules are isolated from the sample, and subjected to fragmenting and joining using ligating agents of one or more hairpin structures to each end of the fragmented nucleic molecules to form one or more dumbbell templates. The one or more dumbbell templates are contacted with at least one substantially complementary primer attached to a substrate, and subjected to rolling circle replication or rolling circle amplification. The resulting replicated dumbbell templates or amplified dumbbell templates are used in numerous genomic applications, including whole genome de novo sequencing; sequence variant detection, structural variant detection, determining the phase of molecular haplotypes, molecular counting for aneuploidy detection; targeted sequencing of gene panels, whole exome, or chromosomal regions for sequence variant detection, structural variant detection, determining the phase of molecular haplotypes and/or molecular counting for aneuploidy detection; study of nucleic acid - nucleic acid binding interactions, nucleic acid - protein binding interactions, and nucleic acid molecule expression arrays; and testing of the effects of small molecule inhibitors or activators or nucleic acid therapeutics.

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