申请人:Dotson Jennafer
公开号:US20120035208A1
公开(公告)日:2012-02-09
Compounds of Formula (I), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer or inflammation mediated by lipid kinases. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
具有化学式(I)的化合物,包括立体异构体、几何异构体、互变异构体、溶剂化物、代谢物和药学上可接受的盐,对于抑制脂质激酶包括p110α和其他PI3K同源物的活性非常有用,用于治疗由脂质激酶介导的癌症或炎症等疾病。本文披露了使用化合物(I)进行体外、原位和体内诊断、预防或治疗哺乳动物细胞中的这些疾病,或相关病理条件的方法。