3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzaldehyde | 1132942-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzaldehyde
• 英文别名: 3-Tert-butyl-5-(2,4-dioxohexahydropyrimidin-1-yl)benzaldehyde；3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)benzaldehyde
• CAS: 1132942-32-5
• 化学式: C₁₅H₁₈N₂O₃
• 分子量: 274.32
• InChiKey: XHYYMSBARLXGTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Anti-Infective Agents and Uses Thereof
  申请人：Wagner Rolf

  公开号：US20110070193A1

  公开（公告）日：2011-03-24

  This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

  本发明涉及：(a) 包括抑制HCV的化合物及其盐等；(b) 用于制备这些化合物和盐的中间体；(c) 包括这些化合物和盐的组合物；(d) 制备这些中间体、化合物、盐和组合物的方法；(e) 使用这些化合物、盐和组合物的方法；以及(f) 包含这些化合物、盐和组合物的试剂盒。
• ANTI-INFECTIVE AGENTS AND USES THEREOF
  申请人：Donner Pamela L.

  公开号：US20120189580A1

  公开（公告）日：2012-07-26

  This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

  本发明涉及：(a)抑制HCV等的化合物及其盐；(b)用于制备此类化合物和盐的中间体；(c)包含此类化合物和盐的组合物；(d)制备此类中间体、化合物、盐和组合物的方法；(e)使用此类化合物、盐和组合物的方法；以及(f)包含此类化合物、盐和组合物的试剂盒。
• N-phenyl-dioxo-hydropyrimidines useful as hepatitis C virus (HCV) inhibitors
  申请人：Abbott Laboratories

  公开号：EP2377854A1

  公开（公告）日：2011-10-19

  This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are useful in the treatment of hepatitis C and are of the following general structure: Formula (I)

  本发明涉及：(a)抑制 HCV 的化合物及其盐类；(b)用于制备此类化合物和盐类的中间体；(c)包含此类化合物和盐类的组合物；(d)制备此类中间体、化合物、盐类和组合物的方法；(e)此类化合物、盐类和组合物的使用方法；以及(f)包含此类化合物、盐类和组合物的试剂盒。这些化合物可用于治疗丙型肝炎，其一般结构如下：式 (I)
• Uracil or thymine derivative for treating hepatitis c
  申请人：AbbVie Bahamas Ltd.

  公开号：EP2725015A1

  公开（公告）日：2014-04-30

  This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; and (e) use of such compounds, salts, and compositions.

  本发明涉及：(a) 除其他外能抑制 HCV 的化合物及其盐类；(b) 用于制备此类化合物和盐类的中间体；(c) 包含此类化合物和盐类的组合物；(d) 制备此类中间体、化合物、盐类和组合物的方法；以及 (e) 此类化合物、盐类和组合物的用途。
• N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS
  申请人：Abbott Laboratories

  公开号：EP2203430B1

  公开（公告）日：2011-06-15