10,10-dibenzyl-9-(4-chloro-benzyl)-9,10-dihydro-anthracene-9-carbonitrile | 103510-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 10,10-dibenzyl-9-(4-chloro-benzyl)-9,10-dihydro-anthracene-9-carbonitrile
• 英文别名: 10,10-Dibenzyl-9-(4-chlor-benzyl)-9-cyan-9,10-dihydro-anthracen；10,10-Dibenzyl-9-(4-chlor-benzyl)-9,10-dihydro-anthracen-9-carbonitril
• CAS: 103510-72-1
• 化学式: C₃₆H₂₈ClN
• 分子量: 510.078
• InChiKey: YFCQMLLKELNOIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.48
• 重原子数：
  38.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  23.79
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  9,10-二氰基蒽 、 苄基氯化镁 在 乙醚 作用下， 生成 10,10-dibenzyl-9-(4-chloro-benzyl)-9,10-dihydro-anthracene-9-carbonitrile
  参考文献：
  名称：

  Rio,G.; Sillion,B., Bulletin de la Societe Chimique de France, 1961, p. 831 - 836

  摘要：

  DOI：

文献信息

• Consequences of sport training during puberty
  作者：James N. Roemmich、E. J. Richmond、A. D. Rogol

  DOI：10.1007/bf03343915

  日期：2001.10

  Growth at puberty depends on one's genetic potential, nutritional status and a series of hormones. Energy expenditure may modify the effects of these three factors on the linear growth rate and the relative proportions of fat-free and fat mass. Participation in sports where weight control is not required does not seem to affect pubertal timing or alter linear growth rate. The growth and maturation of athletes in weight control sports have the additional burden of energy output greater than intake; however, in only a minority the energy deficit is great enough to slow growth and maturation. Studies focusing on male wrestlers and female gymnasts are reviewed. In the wrestlers the hormonal picture is consistent with mild-to-moderate GH resistance and perhaps mild maturational delay, especially in the lower weight classes. The deficits in lean body mass and fat mass "catch-up" quickly following the end of training and competitive season. The situation with the gymnasts is somewhat different, the goal being to develop muscular strength within a shorter and lighter physique. Marked under-nutrition can keep these adolescents pre-pubertal for many years of training and competition. Whether subsequent growth is disproportionate or not remains indeterminate, but the marked delay in the onset of estrogen action can permanently cause the skeleton to be under-mineralized. In conclusion, most athletes continue to track along the centiles of their genetic potential. To define the mechanisms of growth and maturational delay one must longitudinally study children in weight-control sports. (C) 2001, Editrice Kurtis.