1,3-Dioxolo[4,5-f]benzoxazole | 399-09-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 1,3-Dioxolo[4,5-f]benzoxazole
• 英文别名: [1,3]dioxolo[4,5-f][1,3]benzoxazole
• CAS: 399-09-7
• 化学式: C₈H₅NO₃
• 分子量: 163.13
• InChiKey: PIZGAFNKYPRARN-UHFFFAOYSA-N

物化性质

• 沸点：
  266.7±9.0 °C(Predicted)
• 密度：
  1.473±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE
  申请人：Masuda Koji

  公开号：US20110251386A1

  公开（公告）日：2011-10-13

  Disclosed is a compound which is useful as an endothelial lipase inhibitor. A pharmaceutical composition having inhibitory activity on endothelial lipase comprising a compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is nitrogen-containing hetero ring, Ring A may be substituted with a substituent other than a group represented by the formula: —C(R 1 R 2 )—C(═O)—NR 3 R 4 and a group represented by the formula: —R 5 , a broken line represents the presence or the absence of a bond, Z is —NR 6 —, ═N—, —O—, or —S—, R 6 is halogen, substituted or unsubstituted alkyl or the like, R 1 and R 2 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy or substituted or unsubstituted alkyl, R 3 is hydrogen or substituted or unsubstituted alkyl, R 4 is hydrogen, substituted or unsubstituted alkyl or the like, R 3 and R 4 taken together with the adjacent nitrogen atom to which they are attached may form a substituted or unsubstituted ring, R 5 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like.

  公开了一种作为内皮酯酶抑制剂有用的化合物。一种具有内皮酯酶抑制活性的药物组合物，包括下式所示的化合物：其药学上可接受的盐或其溶剂合物，其中，环A是含氮杂环，环A可以被除了由下式表示的基团：—C(R1R2)—C(═O)—NR3R4和由下式表示的基团：—R5以外的基团取代，其中，一条虚线表示键的存在或不存在，Z为—NR6—，═N—，—O—或—S—，R6为卤素，取代或未取代的烷基或类似物，R1和R2各自独立地为氢、卤素、羟基、氰基、硝基、羧基或取代或未取代的烷基，R3为氢或取代或未取代的烷基，R4为氢、取代或未取代的烷基或类似物，R3和R4与它们所连接的相邻氮原子一起可以形成取代或未取代的环，R5为氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基或类似物。
• An electroluminescent element
  申请人：ASAHI KASEI KOGYO KABUSHIKI KAISHA

  公开号：EP0532798A1

  公开（公告）日：1993-03-24

  Disclosed is an electroluminescent element comprising an anode, a cathode and, disposed therebetween, an organic luminescent layer comprising a mixture of a fluorescent luminescent agent, at least one hole moving and donating agent capable of moving holes and donating the same to the luminescent agent and at least one electron moving and donating agent capable of moving electrons and donating the same to the luminescent agent. In the element, the components of the luminescent layer have specific oxidation potential and reduction potential relationships. The element emits light in response to electrical signals. The element exhibits high luminescence efficiency and brightness even at low voltages, and it can efficiently be produced at low cost.

  本发明公开了一种电致发光元件，该元件包括阳极、阴极和置于其间的有机发光层，有机发光层包括荧光发光剂、至少一种能够移动空穴并将空穴捐献给发光剂的空穴移动和捐献剂以及至少一种能够移动电子并将电子捐献给发光剂的电子移动和捐献剂的混合物。在元件中，发光层的各组分具有特定的氧化电位和还原电位关系。该元件在电信号的作用下发光。这种元件即使在低电压下也能表现出很高的发光效率和亮度，而且能以低成本高效生产。
• ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON VASCULAR ENDOTHELIAL LIPASE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2351744A1

  公开（公告）日：2011-08-03

  Disclosed is a compound which is useful as an endothelial lipase inhibitor. A pharmaceutical composition having inhibitory activity on endothelial lipase comprising a compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is nitrogen-containing hetero ring, Ring A may be substituted with a substituent other than a group represented by the formula: -C(R1R2)-C(=O)-NR3R4 and a group represented by the formula: -R5, a broken line represents the presence or the absence of a bond, Z is -NR6-, =N-, -O-, or -S-, R6 is halogen, substituted or unsubstituted alkyl or the like, R1 and R2 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy or substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is hydrogen, substituted or unsubstituted alkyl or the like, R3 and R4 taken together with the adjacent nitrogen atom to which they are attached may form a substituted or unsubstituted ring, R5 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like.

  本发明公开了一种可用作内皮脂肪酶抑制剂的化合物。一种对内皮脂肪酶具有抑制活性的药物组合物，包含一种由式表示的化合物： 、其药学上可接受的盐或其溶液、 其中 环 A 是含氮杂环、 环 A 可被除由式表示的基团以外的取代基取代：-C(R1R2)-C(＝O)-NR3R4和式中代表的基团以外的取代基取代：-R5, 断线表示存在或不存在键、 Z 是-NR6-、＝N-、-O-或-S-、 R6 是卤素、取代或未取代的烷基或类似物、 R1 和 R2 各自独立地是氢、卤素、羟基、氰基、硝基、羧基或取代或未取代的烷基、 R3 是氢、取代或未取代的烷基、 R4 是氢、取代或未取代的烷基或类似物、 R3 和 R4 与它们所连接的相邻氮原子一起可形成一个取代或未取代的环、 R5 是氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基或类似物。
• US5281489A
  申请人：——

  公开号：US5281489A

  公开（公告）日：1994-01-25
• US8957219B2
  申请人：——

  公开号：US8957219B2

  公开（公告）日：2015-02-17