methyl 6-[({3-[(2,2-difluoro-2-phenylethyl)oxy]-5-[(1-methylethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate | 855297-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 6-[({3-[(2,2-difluoro-2-phenylethyl)oxy]-5-[(1-methylethyl)oxy]phenyl}carbonyl)amino]pyridine-3-carboxylate
• 英文别名: Methyl 6-[[3-(2,2-difluoro-2-phenylethoxy)-5-propan-2-yloxybenzoyl]amino]pyridine-3-carboxylate
• CAS: 855297-60-8
• 化学式: C₂₅H₂₄F₂N₂O₅
• 分子量: 470.473
• InChiKey: ULNVIBDYQXGHSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Benzoyl amino pyridyl carboxylic acid derivatives useful as glucokinase (glk) activators
  申请人：Caulkett Peter William Rodney

  公开号：US20090062351A1

  公开（公告）日：2009-03-05

  A compound of Formula (I): Formula (I) wherein: R 1 is selected from hydrogen and C 1-4 alkyl; R 2 is selected from: R 4 —C(R 5a R 5b )—, R 4 ═C(R 6 )— and R 7a C(R 7b )═C(R 6 )—; R 3 X— is selected from methyl, methoxymethyl and; R 4 is selected from (optionally substituted) C 1-4 alkyl, phenyl, C 3-6 cycloalkyl and heteroaryl; R 5a and R 5b are independently selected from hydrogen, fluoro and C 1-4 alkyl; R 6 is selected from hydrogen and C 1-4 alkyl; R 7a and R 7b are optionally substituted C 1-4 alkyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  化合物的化学式（I）：化学式（I），其中：R1选自氢和C1-4烷基；R2选自：R4—C（R5aR5b）—，R4═C（R6）—和R7aC（R7b）═C（R6）—；R3X—选自甲基，甲氧甲基和；R4选自（可选取代的）C1-4烷基，苯基，C3-6环烷基和杂环芳基；R5a和R5b分别选自氢，氟和C1-4烷基；R6选自氢和C1-4烷基；R7a和R7b是可选取代的C1-4烷基；或其盐、前药或溶剂。它们作为GLK激活剂的用途，包含它们的制药组合物以及它们的制备方法也被描述。