4-氨基-N-(6-氧代-1H-嘧啶-2-基)苯磺酰胺 | 56305-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-N-(6-氧代-1H-嘧啶-2-基)苯磺酰胺
• 英文名称: sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide)
• 英文别名: Sulfanilsaeure-(6-oxo-1,6-dihydro-pyrimidin-2-ylamid)；4-amino-N-(6-oxo-1H-pyrimidin-2-yl)benzenesulfonamide
• CAS: 56305-66-9
• 化学式: C₁₀H₁₀N₄O₃S
• 分子量: 266.28
• InChiKey: VSSDCIJVSFIVLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-[4-[[(氨基亚胺甲基)氨基]磺酰基]苯基]-乙酰胺 在 sodium hydroxide 、 水 作用下， 生成 4-氨基-N-(6-氧代-1H-嘧啶-2-基)苯磺酰胺
  参考文献：
  名称：

  Leitch et al., Canadian Journal of Research, Section B: Chemical Sciences, 1947, vol. 25, p. 14,17

  摘要：

  DOI：

文献信息

• A Novel Strategy of Combined Pulsed Electro-Oxidation and Electrolysis for Degradation of Sulfadiazine
  作者：Dong Ma、Bo Zhang、Xiaomin Hu

  DOI：10.3390/molecules28083620

  日期：——

  A combination of the peroxymonosulfate (PMS) electro-activation process and the electro-oxidation process driven by a pulsed electric field (PEF) was used to degrade sulfadiazine (SND) wastewater. Mass transfer is the limiting step of electrochemical processes. The PEF could enhance mass transfer efficiency by reducing the polarization effect and increasing the instantaneous limiting current compared with the constant electric field (CEF), which could benefit the electro-generation of active radicals. The degradation rate of SND after 2 h was 73.08%. The experiments investigated the effects of operating parameters of pulsed power supply, PMS dosage, pH value and electrode inter distance on the degradation rate of SND. The predicted response value of single-factor performance experiments was obtained as 72.26% after 2 h, which was basically consistent with the experimental value. According to the quenching experiments and EPR tests, both SO4•− and •OH were present in the electrochemical processes. The generation of active species were significantly greater in the PEF system than that in the CEF system. Moreover, four kinds of intermediate products were detected during the degradation by LC-MS. This paper presents a new aspect for electrochemical degradation of sulfonamide antibiotics.

  在降解磺胺嘧啶（SND）废水时，采用了过氧化单硫酸盐（PMS）电活化过程和脉冲电场（PEF）驱动的电氧化过程相结合的方法。传质是电化学过程的限制步骤。与恒定电场（CEF）相比，脉冲电场可通过降低极化效应和增加瞬时极限电流来提高传质效率，从而有利于活性自由基的电生成。2 小时后，SND 的降解率为 73.08%。实验研究了脉冲电源、PMS 用量、pH 值和电极间距等操作参数对 SND 降解率的影响。2 h 后，单因素性能实验的预测响应值为 72.26%，与实验值基本一致。根据淬灭实验和 EPR 测试，电化学过程中同时存在 SO4-- 和 -OH。PEF 系统中活性物种的生成量明显高于 CEF 系统。此外，LC-MS 还检测到了降解过程中的四种中间产物。本文为磺胺类抗生素的电化学降解提供了一个新的思路。
• Matsukawa; Yoshida, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 27,29
  作者：Matsukawa、Yoshida

  DOI：——

  日期：——
• Ganapathi et al., Proceedings - Indian Academy of Sciences, Section A, 1942, vol. 16, p. 115,121
  作者：Ganapathi et al.

  DOI：——

  日期：——
• Ohta; Kawasaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 1309,1312
  作者：Ohta、Kawasaki

  DOI：——

  日期：——
• Production of sulfonamides
  申请人：WARD BIENKINSOP &

  公开号：US02471772A1

  公开（公告）日：1949-05-31