2-(7-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronapthalen-2-yl)propanoic acid | 13743-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-(7-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronapthalen-2-yl)propanoic acid
• 英文别名: (S)-2-((R)-7-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydro-[2]naphthyl)-propionic acid；(R)-2-((S)-7-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydro-[2]naphthyl)-propionic acid；(R)-2-((S)-7-Hydroxy-5,8-dimethyl-1,2,3,4-tetrahydro-[2]naphthyl)-propionsaeure；(-)-α-Desmotroposantonigsaeure；Linksdrehende santonige Saeure
• CAS: 13743-98-1；13744-00-8
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: LZCCKQSDOYORKS-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.83
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-(7-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronapthalen-2-yl)propanoic acid 、 三氯化铁 生成 (-)-di-α-desmotroposantonous acid
  参考文献：
  名称：

  Andreocci, Gazzetta Chimica Italiana, 1895, vol. 25 I, p. 521

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 锌 作用下， 生成 2-(7-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronapthalen-2-yl)propanoic acid
  参考文献：
  名称：

  Rapid assessment and delivery of Vitamin A to slum children by using national immunization day in Chandigarh

  摘要：

  This study was done with the objective to see the feasibility of using National Immunization Days (NIDs) for rapid assessment, and delivery of Vitamin A solution to about 27,600 children dwelling in 26 slums in Union Territory of Chandigarh. The assessment of Vitamin A deficiency (VAD) was done in a stratified random sample of 1304 children during third round of Intensified Pulse Polio Immunization (IPPI) and delivery of Vitamin A solution was done during fourth round of IPPI in 1999-2000 covering 27,642 children in the age group of 1-5 years. An additional team of two persons per centre delivered age specific doses of Vitamin A solution through 72 centres and operational problems were recorded. IPPI staff provided supervision and same tally sheets as of IPPI were used. The prevalence rate of VAD was 24.6%, with conjunctival xerosis, bitot's spot and corneal xerosis as 23.7%, 0.6% and 0.2% respectively. 27,275 (98.7%) children out of 27,642 were administered Vitamin A solution, with no major operational problem. Only five parents (0.01%) refused Vitamin A solution. No case of side effect or toxicity due to Vitamin-A was reported. The strategy to assess and deliver Vitamin A during NID's was found to be feasible and successful and could be a basis for launching similar initiatives in other areas of India and other countries where VAD is a public health problem.

  DOI：

  10.1007/bf02752409

文献信息

• Andreocci, Gazzetta Chimica Italiana, 1895, vol. 25 I, p. 545
  作者：Andreocci

  DOI：——

  日期：——
• Huang-Minlon; Wei-Zan Chow, Scientia Sinica (English Edition), 1957, vol. 6, p. 265,276
  作者：Huang-Minlon、Wei-Zan Chow

  DOI：——

  日期：——
• Andreocci; Alessandrello, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, <hi>1899</hi>, vol. <5> 8 I, p. 503
  作者：Andreocci、Alessandrello

  DOI：——

  日期：——