[Cu(II)(2-[(2-hydroxyphenylimino)methyl]phenolate)(2(4-aminophenylsulfonylamino)4,6-dimethylpyrimidine) | 1254249-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Cu(II)(2-[(2-hydroxyphenylimino)methyl]phenolate)(2(4-aminophenylsulfonylamino)4,6-dimethylpyrimidine)
• CAS: 1254249-91-6
• 化学式: C₂₅H₂₃CuN₅O₄S
• 分子量: 553.101
• InChiKey: GIEXPSPWOBHWIF-CAJRCRMVSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-羟基缩苯胺 、 磺胺二甲嘧啶 、 copper diacetate 以 乙醇 为溶剂， 以72%的产率得到[Cu(II)(2-[(2-hydroxyphenylimino)methyl]phenolate)(2(4-aminophenylsulfonylamino)4,6-dimethylpyrimidine)
  参考文献：
  名称：

  Sulfanilamide copper(II) chelates with 2-[(2-hydroxyphenyl-imino)methyl]phenolom and 1-[(2-hydroxyphenylimino)-methyl]naphthalen-2-ol

  摘要：

  2-[(2-Hydroxyphenylimino)methyl]phenol (H(2)L(1)) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (H(2)L(2)) reacted with copper(II) acetate hydrate and sulfanilamide (Sf(1)), sulfathiazole (Sf(2)), sulfaethidole (Sf(3)), sulfadiazine (Sf(4)), and sulfadimidine (Sf(5)) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf(1-5))(L(1-2))center dot nH(2)O (n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (H(2)L(1) and H(2)L(2)) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf1-5) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70-90 degrees C, followed by complete thermal decomposition (290-380 degrees C). The complexes [Cu(Sf(1))(L(1))]center dot 2H(2)O and [Cu(Sf(3))(L(1))]center dot H(2)O at a concentration of 10(-4) M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10(-5) M, whereas no antitumor activity was observed at a concentration of 10(-6) M.

  DOI：

  10.1134/s1070363210070224