Phenoxyharnstoff | 4107-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenoxyharnstoff
• 英文别名: Phenoxyurea
• CAS: 4107-37-3
• 化学式: C₇H₈N₂O₂
• 分子量: 152.153
• InChiKey: LLQHVWGFCDKVOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents
  申请人：Su Tsann-Long

  公开号：US20080171765A1

  公开（公告）日：2008-07-17

  New aniline or phenol N-mustards linked to DNA-affinity carriers (such as 9-anilinoacridines, acridines and quinolines), aminobenzamides or aminophenol ethers by a urea, carbamic acid, carbanic acid ester, hydrazineurea, hydrazinecarbamic acid ester, phenoxyurea, phenoxycarbamic acid ester linkage with improved chemical stability and anti-tumor therapeutic efficacy are provided.

  提供了与DNA亲和载体（如9-苯胺基吖啶、吖啶和喹啉）、氨基苯甲酰胺或氨基酚醚通过脲、碳酸酯、碳酸酯、叠氮脲、叠氮碳酸酯、苯氧基脲、苯氧基碳酸酯链接的新苯胺或酚N-芥子素，具有改善的化学稳定性和抗肿瘤治疗效果。
• Process for the Preparation of a RAF Kinase Inhibitor and Intermediates for Use in the Process
  申请人：Rao Dharmaraj Ramachandra

  公开号：US20100311980A1

  公开（公告）日：2010-12-09

  There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R′ is selected from the group consisting of hydrogen, —C(O)OA, —C(O)CX 3 , —C(O)NH 2 , —C(O)—NHOH or There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.

  提供了一种制备索拉非尼或其盐的方法，包括使用公式（A）的化合物，其中R′从氢、—C（O）OA、—C（O）CX3、—C（O）NH2、—C（O）—NHOH等组成的群体中选择。还提供了一般式（A）的中间化合物，N-甲基-4-(4-脲基苯氧基)吡啶酰胺，4-(2-(甲基氨甲酰)吡啶-4-氧基)苯基氨甲酸酯衍生物和N-甲基-4-(4-(2,2,2-三卤乙酰胺基)苯氧基)吡啶酰胺，以及它们的制备方法和在制备索拉非尼中的应用。
• [EN] PROCESS FOR THE PREPARATION OF A RAF KINASE INHIBITOR AND INTERMEDIATES FOR USE IN THE PROCESS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN INHIBITEUR DE LA KINASE RAF ET INTERMÉDIAIRES UTILISABLES DANS LEDIT PROCÉDÉ
  申请人：CIPLA LTD

  公开号：WO2009034308A2

  公开（公告）日：2009-03-19

  There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A), wherein R' is selected from the group consisting of hydrogen, -C(O)OA, -C(O)CX3, - OH C(O)NH2, -C(O)-NHOH or (a). There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2- (methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2- trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.

  提供了一种制备索拉非尼或其盐的方法，包括使用公式（A）的化合物，其中R'选择自氢，-C（O）OA，-C（O）CX3，-OH C（O）NH2，-C（O）-NHOH或（a）的群。还提供了一般公式（A）的中间体化合物，N-甲基-4-（4-脲基苯氧基）吡啶酰胺，4-（2-（甲基氨基）吡啶-4-氧基）苯基氨基甲酸酯衍生物和N-甲基-4-（4-（2,2,2-三卤乙酰胺）苯氧基）吡啶酰胺，以及它们的制备方法和在制备索拉非尼中的应用。
• Substituted phenoxy urea, processes for its preparation and herbicide containing it as active ingredient
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0183174A2

  公开（公告）日：1986-06-04

  A substituted phenoxy urea having the formula: wherein A is a halogen atom or a trifluoromethyl group, each of X, Y and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, R, is a C1-C6 alkyl group, a lower alkoxyl group, a lower alkoxyl-substituted lower alkyl group, a cyclo-lower alkyl-substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower haloalkyl group, a lower haloalkenyl group or a C3-C9 non-aromatic cyclic hydrocarbon group, and R2 is a hydrogen atom, a C1-C6 alkyl group, a lower alkenyl group or a lower alkynyl group, or R1 and R2 form, together with the nitrogen atom to which they are bonded, a 3-8 member ring (which may be a bicyclo ring) which may contain a double bond or an oxygen atom within the ring and may have one or more branches.

  具有以下式子的取代苯氧基脲 其中 A 为卤原子或三氟甲基，X、Y 和 Z 各为氢原子、卤原子或三氟甲基，R 为 C1-C6 烷基、低级烷氧基、低级烷氧基取代的低级烷基、环低级烷基取代的低级烷基、低级烯基、低级炔基、低级卤代烷基或 C3-C9 非芳香环烃基，R2 为氢原子、C1-C6 烷基、低级卤代烷基或 C3-C9 非芳香环烃基、R2是氢原子、C1-C6 烷基、低级烯基或低级炔基，或者 R1 和 R2 与它们所键合的氮原子一起形成一个 3-8 个成员的环（可以是双环），环内可以含有一个双键或一个氧原子，并可以有一个或多个分支。
• Derivatives of alkylaminoalkyl ureas and cyanoguanidines
  申请人：A.H. ROBINS COMPANY, INCORPORATED

  公开号：EP0295010A1

  公开（公告）日：1988-12-14

  Compounds of general formula I wherein, Ar represents a 1-naphthyl group, a 2-naphthyl group, a 2,3-dihydro-1 H-inden-4(or 5)-yl group, a 2-furanylmethyl group, a 2-pyridinyl group, a phenyl group or a phenyl substituted by one to three substituents wherein the or each substituent independently represents a loweralkyl group, a loweralkoxy group, a diloweralkylamino group, a cyano group, a loweralkylthio group, a loweralkylsulfinyl group, a loweralkylsulfonyl group, an acyl group, an acylamino group, an aminocarbonyl group, a diloweral- kylaminoloweralkoxy group, a trifluoromethyl group, a nitro group or a halogen atom; X represents a thio group, a sulfinyl group, a sulfonyl group or an oxygen atom; d represents zero or one; B represents a carbonyl group, a thioxomethyl group or a cyanoiminomethyl group; each of n, m and p independently represents an integer from 2 to 6 inclusive; each of Z and W independently represent an R group or a group with the proviso that when Z represents R, W represents a -(CH2)m-NR1R2 group and when Z represents (CH2)m-NR1R2, W represents R; each of R, R1, R2, R3 and R4 independently represents a hydrogen atom, a loweralkyl group, a cycloalkyl group, a phenyl group or a phenylloweralkyl group wherein phenyl may be substituted by one to three radicals wherein each radical independently represents a loweralkyl group, a loweralkoxy group, a cyano group, a trifluoromethyl group, a nitro group or a halogen atom or each of R1 and R2, and R3 and R4 may, together with the adjacent nitrogen atom form the heterocyclic ring structure 1-homopiperidinyl, 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl, 1-piperazinyl, or 4-substituted-1-piperazinyl; with the further proviso that some meanings given for the symbols must not be realized simultaneously, as indicated specifically in claim 1, or the pharmaceutically acceptable salts thereof are useful in the treatment of cardiac arrhythmia.

  通式 I 的化合物 其中 Ar 代表 1-萘基、2-萘基、2,3-二氢-1 H-茚-4（或 5）-基、2-呋喃甲基、2-吡啶基、苯基或被一至三个取代基取代的苯基，其中或每个取代基独立地代表低级烷基、一个低级烷氧基、一个低级烷氨基、一个氰基、一个低级烷硫基、一个低级烷基亚磺基、一个低级烷基磺酰基、一个酰基、一个酰氨基、一个氨基羰基、一个低级烷氨基低级烷氧基、一个三氟甲基、一个硝基或一个卤原子； X 代表硫代基团、亚砜基团、磺酰基团或氧原子； d 代表 0 或 1； B 代表羰基、硫氧甲基或氰亚氨基甲基； n、m 和 p 各自独立地代表 2 至 6（含 6）的整数 Z和W各自独立地代表一个R基团或一个 但当 Z 代表 R 时，W 代表-(CH2)m-NR1R2 基团；当 Z 代表 ( )m-NR1R2 时，W 代表 R； R、R1、R2、R3 和 R4 各自独立地代表氢原子、低级烷基、环烷基、苯基或苯基低级烷基，其中苯基可被一至三个基团取代，每个基团独立地代表低级烷基、低级烷氧基、氰基、三氟甲基、硝基或卤素原子或 R1 和 R2 以及 R3 和 R4 中的每一个可与相邻的氮原子一起形成杂环结构 1-高哌啶基、1-哌啶基、4-吗啉基、1-吡咯烷基、1-哌嗪基或 4-取代-1-哌嗪基； 进一步的但书是，如权利要求 1 中特别指出的，符号的某些含义不得同时实现，或其药学上可接受的盐类可用于治疗心律失常。