2-hydroxy-5-(1-hydroxy-2-{2-[4-(2-hydroxy-2-phenyl-ethylamino)-phenyl]-ethylamino}-ethyl)-benzaldehyde | 1021700-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-5-(1-hydroxy-2-{2-[4-(2-hydroxy-2-phenyl-ethylamino)-phenyl]-ethylamino}-ethyl)-benzaldehyde
• 英文别名: 2-Hydroxy-5-[1-hydroxy-2-[2-[4-[(2-hydroxy-2-phenylethyl)amino]phenyl]ethylamino]ethyl]benzaldehyde
• CAS: 1021700-03-7
• 化学式: C₂₅H₂₈N₂O₄
• 分子量: 420.508
• InChiKey: XBUSQTCUZRYVMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  102
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Pteridinone derivatives as PI3-kinases inhibitors
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：EP1953163A1

  公开（公告）日：2008-08-06

  New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.

  根据其作为PI3-激酶调节剂的药理活性，提供了公式1的新化合物，可用于治疗炎症或过敏性疾病的治疗领域。 这些例子包括炎症和过敏性呼吸道疾病，胃肠道和运动器官的炎症性疾病，炎症性和过敏性皮肤疾病，炎症性眼病，鼻黏膜疾病，涉及自身免疫反应或肾脏炎症的炎症性或过敏性疾病。
• Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production
  申请人：Himmelsbach Frank

  公开号：US20110046148A1

  公开（公告）日：2011-02-24

  The present invention relates to spirocyclic heterocycles of general formula (I) the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways, and the preparation thereof.

  本发明涉及一般式(I)的螺环杂环化合物，其包括其互变异构体、立体异构体、它们的混合物和盐，特别是与无机或有机酸形成的生理上可接受的盐，具有有价值的药理特性，特别是对酪氨酸激酶介导的信号传导具有抑制作用，其用于治疗疾病，特别是肿瘤性疾病以及良性前列腺增生（BPH）、肺部和气道疾病，以及其制备方法。
• Inhaler Device for Administering Powered Pharmaceutical Compositions via Inhalation
  申请人：HUANG CAI GU

  公开号：US20180344956A1

  公开（公告）日：2018-12-06

  An inhaler device for administering powdered pharmaceutical composition from capsules comprises of a base, a deck, a chamber, a mouthpiece and a cap. The deck can be latched to the base and closed off, and being connected to a push button ( 17 ) through a protrusion ( 22 ) and a sliding groove ( 16 ). The chamber is for holding the capsules and can be adjusted to be lowered into the base. The mouthpiece is latch-able to the deck. The cap covers the mouthpiece in a closed position and latches it by means of a closure element. The base, the deck, the mouthpiece are connected by means of a spindle. The cap is not connected to the rest of the device parts; instead, it is held together with the rest of the inhaler device by means of the protective shell ( 26 ) with a strip pattern ( 27 ) or a linking belt ( 29 ). Finally, there is a capsule-piercing unit with at least one piercing pin for piercing the capsule.

  一种用于从胶囊中给药粉剂制剂的吸入器装置，包括底座、甲板、腔室、口咀和盖子。甲板可以锁定到底座上并关闭，并通过突起（22）和滑槽（16）连接到推按钮（17）。腔室用于容纳胶囊，并可以调整为降低到底座中。口咀可以锁定到甲板上。盖子在关闭位置下覆盖口咀，并通过闭合元件锁定。底座、甲板、口咀通过一根轴连接。盖子与设备的其余部分没有连接，而是通过带有条纹图案（27）或链接带（29）的保护外壳（26）保持在吸入器设备的其余部分中。最后，有一个至少有一个穿刺针的胶囊穿刺单元，用于穿刺胶囊。
• Inhalation Atomizer Comprising a Blocking Function and a Counter
  申请人：Huang Cai Gu

  公开号：US20190030268A1

  公开（公告）日：2019-01-31

  This invention presents an inhalation atomizer comprising a blocking function through a locking-mechanism and a counter along with a method to discharge and atomize fluid. The apparatus is accommodated in a two part housing, wherein the two parts are mounted to be rotatable relative to each other, and can be blocked through a locking mechanism. The locking mechanism is realized mainly by two protrusions. Protrusion A is located on the outer wall of the lower unit of the inside part. Protrusion B is located on the inner wall of counter. When the inhalation atomizer is actuated each time, the counter will make a rotation with a constant angle around the lower unit of the inside part. Once the predetermined number of actuations has been achieved, Protrusion A and Protrusion B will encounter with each other and hence the counter will be prevented from further rotation. Therefore, the inhalation atomizer is blocked and stopped from further use. The number of actuations of the device can be counted by the counter. Only when sufficient force is applied to destroy the device, this locking state of the device can be overcome. The inhalation atomizer in the current invention can be blocked suitably by this locking-mechanism.

  本发明提供了一种具有锁定机制和计数器的吸入式雾化器，以及一种排放和雾化流体的方法。该装置安装在两部分外壳内，其中两部分可以相对旋转，并可以通过锁定机制被阻止。锁定机制主要由两个突起实现。突起A位于内部部件的下部单元的外壁上。突起B位于计数器的内壁上。当每次启动吸入式雾化器时，计数器将绕内部部件的下部单元旋转一个恒定的角度。一旦达到预定的启动次数，突起A和突起B将相遇，因此计数器将被阻止进一步旋转。因此，吸入式雾化器被阻止并停止进一步使用。计数器可以计算设备的启动次数。只有当施加足够的力破坏设备时，才能克服设备的这种锁定状态。本发明的吸入式雾化器可以通过这种锁定机制适当地被阻止。
• Dichtes Verschließen von gefüllten Arzneimittelkapseln
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：EP2020220A1

  公开（公告）日：2009-02-04

  Die vorliegende Erfindung betrifft ein Verfahren, eine Vorrichtung und ein Steuerprogramm zum fluiddichten Verschließen von Kapseln enthaltend Arzneimittel, wobei die Kapseln aus wenigstens einem Kapselkörper und einer Kapselkappe bestehen, die teleskopartig ineinander gesetzt und im Stoßbereich auf der Kapselaußenseite mit einer dichtenden Banderole versehen werden, wobei die Kapselteile mit einem Gas befüllt werden, welches in Relation zur Umgebung eine geänderte Temperatur und/oder einen geänderten Druck aufweist und wobei ein Differenzdruckminderung in der Kapsel durch Spalte zwischen Kapselkörper und Kapselkappe nach dem ineinander Setzen der Kapselteile stattfindet. Die durch das erfindungsgemäße Verfahren hergestellten Kapseln sind Einweg-Kapseln und enthalten bevorzugt eine Einzeldosis einer oral einnehmbaren pharmazeutischen Formulierung in Form eines Pulvers oder einer Flüssigkeit.

  本发明涉及一种对装有药物的胶囊进行流体密封的方法、装置和控制程序，其中胶囊至少由一个胶囊体和一个胶囊盖组成，胶囊体和胶囊盖以伸缩方式一个置于另一个内，并在胶囊外侧的连接区域设有密封带、其中，胶囊部件中装有相对于环境温度和/或压力发生变化的气体，在胶囊部件一一对应后，通过胶囊体和胶囊帽之间的间隙在胶囊中产生压差。 根据本发明的方法生产的胶囊是一次性胶囊，最好含有粉末或液体形式的单剂量口服药物配方。