<2-(Isopropyl-methyl-amino)-ethyl>-guanidin | 44986-72-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: <2-(Isopropyl-methyl-amino)-ethyl>-guanidin
• 英文别名: [2-(Isopropyl-methyl-amino)-ethyl]-guanidin；2-[2-[Methyl(propan-2-yl)amino]ethyl]guanidine
• CAS: 44986-72-3
• 化学式: C₇H₁₈N₄
• 分子量: 158.247
• InChiKey: BMJXKPVACIHZGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(isopropyl(methyl)amino)ethylamine 、 2-甲基-2-疏基硫酸脲 生成 <2-(Isopropyl-methyl-amino)-ethyl>-guanidin
  参考文献：
  名称：

  Pasini; Coda; Colò, Farmaco, Edizione Scientifica, 1965, vol. 20, # 10, p. 673 - 685

  摘要：

  DOI：

文献信息

• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20150273068A1

  公开（公告）日：2015-10-01

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，其在脂质部分（例如，疏水链）中具有一个或多个可生物降解的基团。这些阳离子脂质可以被纳入到脂质颗粒中，用于传递活性物质，例如核酸。本发明还涉及包括中性脂质、可减少聚集的脂质、本发明中的阳离子脂质和可选地，甾醇的脂质颗粒。该脂质颗粒还可以包括治疗剂，例如核酸。
• Biodegradable lipids for the delivery of active agents
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US10369226B2

  公开（公告）日：2019-08-06

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，该阳离子脂质的脂质分子（如疏水链）中含有一个或多个可生物降解的基团。这些阳离子脂质可掺入脂质颗粒中，用于递送核酸等活性剂。本发明还涉及由中性脂质、能够减少聚集的脂质、本发明的阳离子脂质和可选的固醇组成的脂质颗粒。脂质微粒可进一步包括治疗剂，如核酸。
• IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20150306039A1

  公开（公告）日：2015-10-29

  The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA.
• NUCLEIC ACID LIPID PARTICLE FORMULATIONS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20170233734A1

  公开（公告）日：2017-08-17

  The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA.
• US9061063B2
  申请人：——

  公开号：US9061063B2

  公开（公告）日：2015-06-23