Benzolsulfon-N-(3-chlor-4-tolyl)-amid | 16937-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzolsulfon-N-(3-chlor-4-tolyl)-amid
• 英文别名: N-(3-chloro-4-methylphenyl)benzenesulfonamide
• CAS: 16937-26-1
• 化学式: C₁₃H₁₂ClNO₂S
• mdl: MFCD01212622
• 分子量: 281.763
• InChiKey: YKNGOABEQLEFFP-UHFFFAOYSA-N

物化性质

• 沸点：
  416.9±55.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF p38
  申请人：Bemis Guy W.

  公开号：US20110281878A1

  公开（公告）日：2011-11-17

  The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明涉及p38的抑制剂，p38是一种哺乳动物蛋白激酶，参与细胞增殖、细胞死亡和对细胞外刺激的反应。本发明还涉及制备这些抑制剂的方法。本发明还提供了包含本发明抑制剂的药物组合物，并提供了利用这些组合物治疗和预防各种疾病的方法。
• Alkyl substituted photographic couplers and photographic elements and processes employing same
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0482609A1

  公开（公告）日：1992-04-29

  A coupler having as a coupling-off group an alkyl group substituted with an electron source capable of stabilizing a carbonium ion enables formation of a dye image in a photographic silver halide material.

  一种耦合剂具有一个被电子源取代的烷基作为耦合基团，该电子源能够稳定羰离子，从而在照相卤化银材料中形成染料图像。
• Inhibitors of p38
  申请人：Salituro Francesco

  公开号：US20070060572A1

  公开（公告）日：2007-03-15

  The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
• US5091291A
  申请人：——

  公开号：US5091291A

  公开（公告）日：1992-02-25
• US7186737B2
  申请人：——

  公开号：US7186737B2

  公开（公告）日：2007-03-06