2-Hydroxy-5-[1-(4-hydroxy-phenyl)-1-methyl-ethyl]-benzoic acid | 101949-49-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-5-[1-(4-hydroxy-phenyl)-1-methyl-ethyl]-benzoic acid
• 英文别名: 2-Hydroxy-5-[2-(4-hydroxyphenyl)propan-2-yl]benzoic acid
• CAS: 101949-49-9
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: PMMUFDGWDXRPRQ-UHFFFAOYSA-N

物化性质

• 熔点：
  159 - 161°C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-5-[1-(4-hydroxy-phenyl)-1-methyl-ethyl]-benzoic acid 、 ditert-butyl (2S)-2-[[2-[(3aR,4S,6R,7R,7aS)-6-(aminomethyl)-7-hydroxy-2,2-dimethyl-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yl]acetyl]amino]pentanedioate 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 作用下， 生成 (S)-2-{2-[(3aR,4S,6R,7R,7aS)-7-Hydroxy-6-({2-hydroxy-5-[1-(4-hydroxy-phenyl)-1-methyl-ethyl]-benzoylamino}-methyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-acetylamino}-pentanedioic acid di-tert-butyl ester
  参考文献：
  名称：

  β-C-Mannosides as Selectin Inhibitors

  摘要：

  Potential E- and P-selectin inhibitors were synthesized to explore a hydrophobic area on the E-selectin surface and the PSGL-1 protein binding site on the P-selectin surface that was recently defined by crystallography. Three series of mannose-based compounds (libraries A, B, and C) were synthesized using solution phase parallel synthesis. Biological evaluation of these compounds was done using two ELISA-based assays and transferred NOE (trNOE) experiments. Some of the compounds showed better activity than sLe(x) in the P-selectin assay.

  DOI：

  10.1021/jm010390f
• 作为产物：
  描述：

  双酚A 生成 2-Hydroxy-5-[1-(4-hydroxy-phenyl)-1-methyl-ethyl]-benzoic acid
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• POLYCARBONATE COMPRISING DIFFERENT KINDS OF BONDING UNITS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0885912A1

  公开（公告）日：1998-12-23

  Disclosed is a polycarbonate comprising a plurality of aromatic polycarbonate main chains, wherein the aromatic polycarbonate main chains collectively contain specific heterounits in a specific amount in the polycarbonate main chains. The polycarbonate of the present invention can be obtained by controlling the temperature of and the residence time of the polymerizable material in the reaction zones of the reaction system so as to satisfy the specific requirements. The polycarbonate of the present invention is advantageous in that not only does it have high transparency and colorlessness as well as high mechanical strength, but also it can exhibit high non-Newtonian flow properties, so that it exhibits high molding melt fluidity. Therefore, the polycarbonate of the present invention is extremely advantageous from a commercial point of view.

  本发明公开了一种聚碳酸酯，该聚碳酸酯由多个芳香族聚碳酸酯主链组成，其中芳香族聚碳酸酯主链在聚碳酸酯主链中共同含有特定数量的特定异构体。本发明的聚碳酸酯可通过控制可聚合材料在反应系统反应区的温度和停留时间来获得，以满足特定要求。本发明的聚碳酸酯的优点在于，它不仅具有高透明度、无色性和高机械强度，而且还能表现出较高的非牛顿流动特性，从而表现出较高的成型熔体流动性。因此，从商业角度来看，本发明的聚碳酸酯极具优势。
• RESIN COMPOSITION
  申请人：Teijin Chemicals, Ltd.

  公开号：EP1038920A1

  公开（公告）日：2000-09-27

  A resin composition comprising 100 parts by weight of a resin component selected from (a) an aromatic polycarbonate resin (A-1 component) obtained by melt polymerization and, when measured for fluorescent spectrum at an exciting wavelength of 320 nm, having a relative fluorescence intensity of 4x10-3 or less at 465 nm relative to a standard substance, (b) a resin mixture of said A-1 component and a styrene-based resin (A-2 component), and (c) a resin mixture of said A-1 component and an aromatic polyester resin (A-3 component), and 5 to 200 parts by weight of a reinforcing filler. This resin composition gives a molded article superior in wet heat fatigue and various physical properties.

  (b) 上述 A-1 组分和苯乙烯基树脂（A-2 组分）的树脂混合物，以及 (c) 上述 A-1 组分和芳香族聚酯树脂（A-3 组分）的树脂混合物。这种树脂组合物可使模塑制品具有更佳的湿热疲劳性能和各种物理性能。
• PROCESS FOR PRODUCING AROMATIC CARBONATE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1829854A1

  公开（公告）日：2007-09-05

  Production of an aromatic carbonic ester through an ester exchange reaction between a starting material and a reactant while distilling by-product alcohols and/or by-product dialkyl carbonates off the reaction system, wherein use is made of a specified catalyst.

  通过起始原料和反应物之间的酯交换反应生产芳香族碳酸酯，同时从反应体系中蒸馏出副产物醇和/或副产物二烷基碳酸酯，其中使用特定的催化剂。
• Aromatic polycarbonate composition, process for producing the same, and hollow container therefrom
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2143750A1

  公开（公告）日：2010-01-13

  A subject for the invention is to provide a branched aromatic polycarbonate which is excellent in hue and in melt characteristics such as melt strength. The invention provides a process for an aromatic polycarbonate composition comprising an aromatic polycarbonate, a carbonic diester compound and a dye, said process comprising producing the aromatic polycarbonate by a transesterification method and adding the dye after a catalyst used for the transesterification method is deactivated and before a pelletization, wherein the aromatic polycarbonate has a viscosity-average molecular weight of 16,000 or higher, the ratio of the weight-average molecular weight (Mw) to the number-average molecular weight (Mn) of the aromatic polycarbonate as measured by gel permeation chromatography and calculated for standard polystyrene (Mw/Mn) is in the range of from 2.8 to 4.5, the content of the carbonic diester compound in the aromatic polycarbonate composition is 200 ppm by weight or less, the dye is one or more compounds selected from Phthalocyanine Blue dyes and anthraquinone dyes and the content of the dye in the aromatic polycarbonate composition is from 0.01 ppm by weight to 100 ppm by weight. The invention further provides an aromatic polycarbonate composition comprising an aromatic polycarbonate and a carbonic diester compound.

  本发明的目的是提供一种支化芳香族聚碳酸酯，其色调和熔体特性（如熔体强度）都很好。 本发明提供了一种芳香族聚碳酸酯组合物的工艺，该组合物包括芳香族聚碳酸酯、碳酸二酯化合物和染料，所述工艺包括通过酯交换法生产芳香族聚碳酸酯，并在酯交换法所用催化剂失活后和造粒前加入染料、其中芳香族聚碳酸酯的粘均分子量为 16,000 或更高，通过凝胶渗透色谱法测量并按标准聚苯乙烯计算的芳香族聚碳酸酯的重均分子量（Mw）与数均分子量（Mn）之比（Mw/Mn）在 2.8至4.5，芳香族聚碳酸酯组合物中碳酸二酯化合物的含量为200ppm（重量）或更少，染料为选自酞菁蓝染料和蒽醌染料的一种或多种化合物，芳香族聚碳酸酯组合物中染料的含量为0.01ppm（重量）至100ppm（重量）。 本发明进一步提供了一种芳香族聚碳酸酯组合物，该组合物由芳香族聚碳酸酯和碳酸二酯化合物组成。
• METHOD FOR PRODUCING BRANCHED AROMATIC POLYCARBONATE RESIN
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2883899A1

  公开（公告）日：2015-06-17

  The present invention provides a method for producing a branched aromatic polycarbonate resin that is molecular weight-increased, which comprises subjecting an aromatic polycarbonate prepolymer and a linking agent comprising a trifunctional or more of an aliphatic polyol compound to transesterification reaction in the presence of a transesterification catalyst under a reduced pressure condition.

  本发明提供了一种生产分子量增加的支链芳香族聚碳酸酯树脂的方法，该方法包括在减压条件下，将芳香族聚碳酸酯预聚物和由三官能团或更多脂肪族多元醇化合物组成的连接剂在酯交换催化剂存在下进行酯交换反应。