(1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid | 2304372-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid
• 英文别名: Pocenbrodib；(1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)-hydroxymethyl]-6-methoxycarbonyl-7-methyl-8,9-dihydro-7H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid
• CAS: 2304372-79-8
• 化学式: C₂₈H₃₂FN₃O₆
• 分子量: 525.577
• InChiKey: NOUKMOKAEKAWKS-FSEQIFNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid 在 硫酸 作用下， 以 乙酸乙酯 为溶剂， 生成 (1R,3R)-3-((S)-2-((R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl)-6-(methoxycarbonyl)-7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolin-3-yl)cyclohexane-1-carboxylic sulfuric acid salt
  参考文献：
  名称：

  INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) BINDING PROTEIN (CBP)

  摘要：

  本公开涉及由盐和晶体形式组成的CBP/p300家族溴域抑制剂的固体和盐形式，其化学式为(I)。这些化合物可以用于治疗与CBP/p300家族溴域抑制剂抑制相关的疾病或疾病。例如，本公开涉及抑制CBP/p300家族溴域的化合物和组合物，治疗与CBP/p300家族溴域抑制剂抑制相关的疾病或疾病的方法（例如某些癌症），以及这些化合物的合成方法。

  公开号：

  US20220089594A1
• 作为产物：
  描述：

  2-(5-fluoro-2-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile 在 trilithium citrate 、 三氟乙酸 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 生成 (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid
  参考文献：
  名称：

  INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) BINDING PROTEIN (CBP)

  摘要：

  本公开涉及由盐和晶体形式组成的CBP/p300家族溴域抑制剂的固体和盐形式，其化学式为(I)。这些化合物可以用于治疗与CBP/p300家族溴域抑制剂抑制相关的疾病或疾病。例如，本公开涉及抑制CBP/p300家族溴域的化合物和组合物，治疗与CBP/p300家族溴域抑制剂抑制相关的疾病或疾病的方法（例如某些癌症），以及这些化合物的合成方法。

  公开号：

  US20220089594A1

文献信息

• [EN] TETRAHYDRO-IMIDAZO QUINOLINE COMPOSITIONS AS CBP/P300 INHIBITORS<br/>[FR] COMPOSITIONS DE TÉTRAHYDROIMIDAZO QUINOLÉINE UTILISÉES EN TANT QU'INHIBITEURS DE CBP/P300
  申请人：FORMA THERAPEUTICS INC

  公开号：WO2019055877A1

  公开（公告）日：2019-03-21

  The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

  本公开内容涉及CBP/p300家族溴结构域的抑制剂。这些化合物可用于治疗与CBP/p300家族溴结构域抑制相关疾病或障碍。例如，本公开内容涉及用于抑制CBP/p300家族溴结构域的化合物和组合物，治疗、预防或改善与CBP/p300家族溴结构域抑制相关的疾病或障碍的方法，以及这些化合物的合成方法。
• BROMODOMAIN INHIBITORS FOR ANDROGEN RECEPTOR-DRIVEN CANCERS
  申请人：FORMA Therapeutics, Inc.

  公开号：US20220088005A1

  公开（公告）日：2022-03-24

  Methods for treating certain androgen receptor-positive forms of cancer using inhibitors of the CREB binding protein bromodomain are disclosed. In some methods, the AR-positive forms of cancer may be breast cancer, including triple negative forms, hormone receptor positive forms, and HER2-positive forms. In other methods, the AR-positive forms of cancer may be prostate cancer, including metastatic castration resistant prostate cancer. In some embodiments, methods of treating prostate cancer comprise the step of administering to a patient in need thereof the compound (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

  本文披露了使用CREB结合蛋白溴域抑制剂治疗某些雄激素受体阳性的癌症的方法。在某些方法中，AR阳性的癌症可能是乳腺癌，包括三阴性、激素受体阳性和HER2阳性形式。在其他方法中，AR阳性的癌症可能是前列腺癌，包括转移后的去势抵抗性前列腺癌。在某些实施例中，治疗前列腺癌的方法包括向需要的患者施用化合物（1R，3R）-3-[(7S)-2-[(R)-(5-氟-2-甲氧基苯基)(羟基)甲基]-6-(甲氧羰基)-7-甲基-3H，6H，7H，8H，9H-咪唑[4，5-f]喹啉-3-基]环己烷-1-羧酸或其药学上可接受的盐。
• INHIBITING CREB BINDING PROTEIN (CBP)
  申请人：Forma Therapeutics, Inc.

  公开号：EP3998266A1

  公开（公告）日：2022-05-18

  The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

  本公开涉及 CBP/p300 系列溴结构域的抑制剂。这些化合物可用于治疗与抑制 CBP/p300 家族溴结构域相关的疾病或紊乱。例如，本公开涉及用于抑制 CBP/p300 家族溴基链的化合物和组合物，治疗、预防或改善与抑制 CBP/p300 家族溴基链相关的疾病或紊乱的方法，以及合成这些化合物的方法。
• Inhibiting CREB binding protein (CBP)
  申请人：FORMA Therapeutics, Inc.

  公开号：US10870648B2

  公开（公告）日：2020-12-22

  The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

  本公开涉及 CBP/p300 系列溴结构域的抑制剂。这些化合物可用于治疗与抑制 CBP/p300 家族溴结构域相关的疾病或紊乱。例如，本公开涉及用于抑制 CBP/p300 家族溴基链的化合物和组合物，治疗、预防或改善与抑制 CBP/p300 家族溴基链相关的疾病或紊乱的方法，以及合成这些化合物的方法。
• Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
  申请人：FORMA Therapeutics, Inc.

  公开号：US11292791B2

  公开（公告）日：2022-04-05

  The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

  本公开涉及 CBP/p300 系列溴结构域的抑制剂。这些化合物可用于治疗与抑制 CBP/p300 家族溴结构域相关的疾病或紊乱。例如，本公开涉及用于抑制 CBP/p300 家族溴基链的化合物和组合物，治疗、预防或改善与抑制 CBP/p300 家族溴基链相关的疾病或紊乱的方法，以及合成这些化合物的方法。