(R)-3-biphenyl-4-ylmethyl-N-(3-carboxy-propyl)succinamic acid tert-butyl ester | 1257446-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-3-biphenyl-4-ylmethyl-N-(3-carboxy-propyl)succinamic acid tert-butyl ester
• 英文别名: 4-[[(2R)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-[(4-phenylphenyl)methyl]butanoyl]amino]butanoic acid
• CAS: 1257446-46-0
• 化学式: C₂₅H₃₁NO₅
• 分子量: 425.525
• InChiKey: LKNSHSXTGQMOQV-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS
  申请人：COPPOLA Gary Mark

  公开号：US20140296240A1

  公开（公告）日：2014-10-02

  The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , B 1 , X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了式I'的化合物；或其药学上可接受的盐，其中R1、R2、R3、R5、B1、X和n在此定义。本发明还涉及制造本发明化合物的方法及其治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。
• Substituted Aminopropionic Derivatives as Neprilysin inhibitors
  申请人：Coppola Gary Mark

  公开号：US20100305131A1

  公开（公告）日：2010-12-02

  The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , B 1 , X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了式I'的化合物；或其药学上可接受的盐，其中R1、R2、R3、R5、B1、X和n在此定义。本发明还涉及制造该化合物的方法及其治疗用途。本发明进一步提供了一种药理活性剂的组合和制药组合物。
• POLYCARBONATE RESIN COMPOSITION, AND MOLDED ARTICLE, FILM, PLATE AND INJECTION-MOLDED ARTICLE EACH COMPRISING SAME
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2594608A1

  公开（公告）日：2013-05-22

  The invention is to provide a polycarbonate resin composition and a molded polycarbonate resin article which combine excellent transparency and strength and which are suitable for use in the field of building materials, electrical/electronic field, automotive field, field of optical parts, etc. The invention relates to a polycarbonate resin composition containing a polycarbonate resin and an impact strength modifier, the polycarbonate resin containing structural units which are derived from a dihydroxy compound that has the portion represented by the following general formula (1) as part of the structure thereof and having a glass transition temperature lower than 145°C and a molded polycarbonates resin article obtained by molding the composition. The polycarbonate resin composition gives a molded object having a thickness of 3 mm which has a total light transmittance of 60% or higher.

  本发明旨在提供一种聚碳酸酯树脂组合物和一种模塑聚碳酸酯树脂制品，它们兼具优异的透明度和强度，适用于建筑材料领域、电气/电子领域、汽车领域、光学部件领域等。本发明涉及一种含有聚碳酸酯树脂和抗冲击强度改性剂的聚碳酸酯树脂组合物，该聚碳酸酯树脂含有由二羟基化合物衍生的结构单元，该二羟基化合物的部分结构由以下通式（1）表示，其玻璃化转变温度低于 145°C，本发明还涉及通过模塑该组合物获得的模塑聚碳酸酯树脂制品。该聚碳酸酯树脂组合物可制成厚度为 3 毫米的模塑物，其总透光率为 60% 或更高。
• Substituted aminopropionic derivatives as neprilysin inhibitors
  申请人：Novartis AG

  公开号：EP2594556A1

  公开（公告）日：2013-05-22

  The present invention provides a compound of formula I'; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种式 I' 的化合物； 或其药学上可接受的盐，其中 R1、R2、R3、R5、B1、X 和 n 在本文中定义。本发明还涉及一种制造本发明化合物的方法及其治疗用途。本发明进一步提供了药理活性剂和药物组合物的组合。
• POLYCARBONATE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2692798A1

  公开（公告）日：2014-02-05

  The present invention provides a polycarbonate resin composition with an excellent balance of weather resistance, impact resistance, light-blocking effect and the like, and a molded article thereof. The present invention relates to a polycarbonate resin composition, comprising: a polycarbonate resin containing a structural unit derived from a dihydroxy compound having a moiety represented by the following formula (1) [provided that a case where the moiety represented by formula (1) is a moiety constituting -CH2-O-H is excluded]; and an elastomer composed of a core•shell structure, wherein a core layer of the elastomer is at least one member selected from the group consisting of an alkyl (meth)acrylate and a (meth)acrylic acid, and a polycarbonate resin molded article obtained by molding the polycarbonate resin composition.

  本发明提供了一种在耐候性、抗冲击性、遮光效果等方面具有良好平衡的聚碳酸酯树脂组合物及其模塑制品。本发明涉及一种聚碳酸酯树脂组合物，包括聚碳酸酯树脂，其结构单元来源于具有下式（1）所代表分子的二羟基化合物[但不包括式（1）所代表的分子是由-CH2-O-H 构成的分子的情况]；以及由芯壳结构组成的弹性体，其中弹性体的芯层是至少一种选自烷基（甲基）丙烯酸酯和（甲基）丙烯酸组成的组的成员，以及通过模塑该聚碳酸酯树脂组合物而获得的聚碳酸酯树脂模塑制品。