Pt(4-methoxybenzaldehyde thiosemicarbazone(-1H))(PPh3) | 1400674-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Pt(4-methoxybenzaldehyde thiosemicarbazone(-1H))(PPh3)
• CAS: 1400674-72-7
• 化学式: C₁₈H₂₂N₆PtS₂
• 分子量: 581.625
• InChiKey: NWXMFXUIUFIXJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 4-methylbenzaldehyde thiosemicarbazone 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以68%的产率得到Pt(4-methoxybenzaldehyde thiosemicarbazone(-1H))(PPh3)
  参考文献：
  名称：

  Benzaldehyde thiosemicarbazone complexes of platinum: Syntheses, structures and cytotoxic properties

  摘要：

  The reaction of 4-R-benzaldehyde thiosemicarbazones (denoted in general as H2L-R, where H-2 stands for the two dissociable protons and R (R = OCH3, CH3, H, Cl and NO2) for the substituent on the phenyl ring) with [Pt(PPh3)(2)Cl-2] in the presence of NEt3 afforded a family of organometallic complexes of platinum(II) of the type [Pt(PPh3)(L-R)]. Reaction of the same group of ligands with K-2[PtCl4] in the presence of NEt3 afforded complexes of the type [Pt(HL-R)(2)]. The crystal structure of [Pt(PPh3)(L-CH3)] and [Pt(HL-CH3)(2)] have been determined. In the [Pt(PPh3)(L-R)] complexes, the benzaldehyde thiosemicarbazones are coordinated to platinum as dianionic tridentate C,N,S-donors. In the [Pt(HL-R)(2)] complexes, the benzaldehyde thiosemicarbazones are coordinated to the metal center as bidentate N,S-donors, forming five-membered chelate rings, and with reference to the structure of the uncoordinated thiosemicarbazone ligand, this coordination mode is associated with a change in stereochemistry around the C=N bond. All the [Pt(PPh3)(L-R)] and [Pt(HL-R)(2)] complexes display intense absorptions in the visible and ultraviolet regions. The cytotoxic effects of these complexes, examined on the human leukemia cell line HL-60 and human lymphoma cell line U-937, have shown that all the [Pt(PPh3)(L-R)] and [Pt(HL-R)(2)] complexes are cytotoxic in nature and their IC50 values indicate their potential use as antitumor agents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.07.037