2-(4-氟苯基)异烟醛 | 1214368-14-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(4-氟苯基)异烟醛
• 英文名称: 2-(4-fluorophenyl)pyridine-4-carbaldehyde
• 英文别名: 2-(4-Fluorophenyl)isonicotinaldehyde
• CAS: 1214368-14-5
• 化学式: C₁₂H₈FNO
• 分子量: 201.2
• InChiKey: UMICIVXTBAEPGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

文献信息

• [EN] INHIBITORS OF HEPATITIS C VIRUS POLYMERASE<br/>[FR] INHIBITEURS DE LA POLYMÉRASE DU VIRUS DE L'HÉPATITE C
  申请人：COCRYSTAL DISCOVERY INC

  公开号：WO2012083105A1

  公开（公告）日：2012-06-21

  The present invention provides, among other things, compounds represented by the general Formula (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.

  本发明提供了一种由一般式（I）表示的化合物及其药用盐，其中X、Y、R1A、R1B、R2和R3如本文中的类和子类中所定义，并包括含有这种化合物的组合物（例如，药物组合物），这些化合物可用作丙型肝炎病毒聚合酶的抑制剂，因此可用作治疗HCV感染的药物。
• GLYCINE TRANSPORTER INHIBITING SUBSTANCES
  申请人：Moriya Minoru

  公开号：US20130184460A1

  公开（公告）日：2013-07-18

  The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

  本发明旨在提供基于甘氨酸摄取抑制作用的化合物的新颖化合物，其化学式为[I]或其药学上可接受的盐，可用于预防或治疗精神分裂症、阿尔茨海默病、认知功能障碍、痴呆、焦虑障碍（广泛性焦虑障碍、恐慌障碍、强迫症、社交焦虑障碍、创伤后应激障碍、特定恐惧症、急性应激障碍等）、抑郁症、药物成瘾、痉挛、震颤、疼痛和睡眠障碍等疾病的预防或治疗。
• GLYCINE TRANSPORTER INHIBITOR
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP2617715A1

  公开（公告）日：2013-07-24

  The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

  本发明旨在提供基于甘氨酸摄取抑制作用的新型式[I]化合物或其药学上可接受的盐，这些化合物可用于预防或治疗精神分裂症、阿尔茨海默病、认知功能障碍、痴呆症、焦虑症（广泛性焦虑症、恐慌症、强迫症、社交焦虑症、创伤后应激障碍、特殊恐惧症、急性应激障碍等）等疾病。抑郁症、药物成瘾、痉挛、震颤、疼痛和睡眠障碍）：
• Inhibitors of hepatitis C virus polymerase
  申请人：COCRYSTAL DISCOVERY, INC.

  公开号：US10426762B2

  公开（公告）日：2019-10-01

  The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.

  本发明除其他外，提供了通式 I 所代表的化合物：及其药学上可接受的盐，其中 X、Y、R2 和 R3 如本文类和亚类所定义，以及包含此类化合物的组合物（例如药物组合物），这些化合物可用作丙型肝炎病毒聚合酶的抑制剂，因此可用作治疗 HCV 感染的药物等。
• INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
  申请人：Cocrystal Discovery, Inc.

  公开号：EP2651906A1

  公开（公告）日：2013-10-23