Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
公开了用于治疗炎症和纤维化疾病的化合物和方法,包括用活性化合物调节应激活化蛋白激酶(
SAPK)系统的方法,其中活性化合物对p38
MAPK的抑制效力较低;并且其中接触是在
SAPK调节浓度下进行的,该浓度对化合物抑制p38
MAPK的抑制浓度百分比较低。还公开了
吡非尼酮的衍
生物和类似物,它们可用于调节应激活化蛋白激酶(
SAPK)系统。