4-chloro-3-hydroxy-1H-pyridin-2-one | 19365-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-chloro-3-hydroxy-1H-pyridin-2-one
• 英文别名: 4-Chloropyridine-2,3-diol；4-chloro-3-hydroxy-1H-pyridin-2-one
• CAS: 19365-20-9
• 化学式: C₅H₄ClNO₂
• mdl: MFCD22547510
• 分子量: 145.545
• InChiKey: UCJLJSZCMMWOGH-UHFFFAOYSA-N

物化性质

• 沸点：
  296.8±40.0 °C(Predicted)
• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 3-CYANO-QUINOLINE DERIVATIVES AS NON-RECEPTOR TYROSINE KINASE INHIBITORS<br/>[FR] DERIVES DE LA 3-CYANO-QUINOLEINE, EN TANT QU'INHIBITEURS DE TYROSINE KINASE NON RECEPTEURS
  申请人：ASTRAZENECA AB

  公开号：WO2004069249A1

  公开（公告）日：2004-08-19

  The invention concerns quinoline derivatives of: (Formula I) (A chemical formula should be inserted here - please see paper copy enclosed herewith) wherein Z is an O, S, SO, SO2, N(R2) or C(R2)(R3) group wherein each R2 or R3 group is hydrogen or (1-6C)alkyl, m is 1, 2 or 3, each R1 group is selected from halogeno, (1-6C)alkyl, (1-6C)alkoxy and any of the other meanings defined in the description, Ra is hydrogen or halogeno, Rb is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy, Rc is (1-6C)alkoxy and Rd is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy, or Rc and Rd together form a (1-3C)alkylenedioxy group, or pharmaceutically acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.

  该发明涉及喹啉衍生物：(化学式I) （此处应插入化学式 - 请参阅随函附上的纸质副本），其中Z为O、S、SO、SO2、N(R2)或C(R2)(R3)基团，其中每个R2或R3基团为氢或(1-6C)烷基，m为1、2或3，每个R1基团从卤代烷基、(1-6C)烷基、(1-6C)烷氧基和描述中定义的其他含义中选择，Ra为氢或卤代基，Rb为氢、卤代基、(1-6C)烷基或(1-6C)烷氧基，Rc为(1-6C)烷氧基，Rd为氢、卤代基、(1-6C)烷基或(1-6C)烷氧基，或Rc和Rd一起形成(1-3C)烷基二氧基基团，或其药学上可接受的盐；它们的制备方法，含有它们的药物组合物以及它们在制造用作抗侵袭剂的药物的用途中在固体肿瘤疾病的控制和/或治疗中的使用。
• NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING
  申请人：P & G-Clairol, Inc.

  公开号：EP1333794A1

  公开（公告）日：2003-08-13
• EP1333794A4
  申请人：——

  公开号：EP1333794A4

  公开（公告）日：2005-08-10
• [EN] NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING<br/>[FR] NOUVEL AGENT DE COUPLAGE DESTINE A ETRE UTILISE POUR LA COLORATION CAPILLAIRE OXYDANTE
  申请人：CLAIROL INC

  公开号：WO2002039969A1

  公开（公告）日：2002-05-23

  Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R2SO4; R3 is selected from C¿1? to c2 alkyl or hydroxyethyl; R?2¿ is selected from C¿1? to C22 alkyl and C1 to C22 mono and dihydroxyalkyl; and R is selected from of C1 to C16 alkyl, C1 to c10 hydroxyalkyl, C1 to C6 alkoxyalkyl and benzyl.