3-methylphthalamide | 63089-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methylphthalamide
• 英文别名: 3-Methylphthalamid；3-Methylbenzene-1,2-dicarboxamide
• CAS: 63089-46-3
• 化学式: C₉H₁₀N₂O₂
• 分子量: 178.191
• InChiKey: ANUCJOYKFWJABK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methylphthalamide 在 铵 、 氨 作用下， 生成 4-甲基-异二氢吲哚-1,3-二酮
  参考文献：
  名称：

  McClelland, Robert A.; Seaman, N. Esther; Duff, James M., Canadian Journal of Chemistry, 1985, vol. 63, p. 121 - 128

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-异二氢吲哚-1,3-二酮 在 氨 作用下， 90.0 ℃ 、5.79 MPa 条件下， 反应 20.0h， 以56%的产率得到3-methylphthalamide
  参考文献：
  名称：

  McClelland, Robert A.; Seaman, N. Esther; Duff, James M., Canadian Journal of Chemistry, 1985, vol. 63, p. 121 - 128

  摘要：

  DOI：

文献信息

• Synthesis of phthalic acid derivatives <i>via</i> Pd-catalyzed alkoxycarbonylation of aromatic C–H bonds with alkyl chloroformates
  作者：Gang Liao、Hao-Ming Chen、Bing-Feng Shi

  DOI：10.1039/c8cc06663a

  日期：——

  A Pd(II)-catalyzed alkoxycarbonylation of aromatic C–H bonds with alkyl chloroformates has been developed. A broad range of benzamides and alkyl chloroformates are compatible with this protocol. The reaction is operationally simple and scalable. The direct group could be readily removed to access substituted phthalic acid esters (PAEs), 1,2-dibenzyl alcohols and phthalamides. Besides alkoxycarbonylation

  已经开发了钯（II）催化的带有烷基氯甲酸酯的芳香族碳氢键的烷氧基羰基化反应。各种各样的苯甲酰胺和烷基氯甲酸酯都与此协议兼容。该反应操作简单且可扩展。可以容易地除去直接基团以得到取代的邻苯二甲酸酯（PAE），1，2-二苄基醇和邻苯二甲酰胺。除了苯甲酰胺β-CH键的烷氧羰基化以外，2-苯基乙酰胺的γ-烷氧羰基化也是可行的。
• [EN] SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP)<br/>[FR] PYRIDONES SUBSTITUES INHIBITEURS DE LA POLY(ADP-RIBOSE) POLYMERASE (PARP)
  申请人：AVENTIS PHARMA INC

  公开号：WO2005097750A1

  公开（公告）日：2005-10-20

  The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

  本发明公开并声明了一系列如下定义的2,3,5-取代吡啶酮衍生物。本发明还涉及制备这些化合物的方法。本发明的化合物是多聚腺苷酸二磷酸核糖酶（PARP）的抑制剂，因此在制药剂中特别用于治疗和/或预防各种疾病，包括与中枢神经系统和心血管疾病相关的疾病。
• PROCESS FOR PREPARING ISOCYANATES
  申请人：Mattke Torsten

  公开号：US20120253063A1

  公开（公告）日：2012-10-04

  Process for preparing aromatic isocyanates by reacting the corresponding formamides with an oxygen-comprising gas over noble metal catalysts at temperatures of from 300 to 600° C. and a contact time of from 1 to 1000 ms, wherein: a. the formamide is vaporized before entering the reaction zone, b. the reaction mixture obtained is quenched with an alcohol-comprising quenching liquid and c. the urethane formed is dissociated into isocyanate and alcohol.

  制备芳香异氰酸盐的过程是通过在300至600℃的温度下，将相应的甲酰胺与含氧气体在贵金属催化剂上反应，反应时间为1至1000毫秒。其中，a.在进入反应区之前，甲酰胺被蒸发；b.所得到的反应混合物用含醇淬火液淬火；c.生成的脲酸酯被解离成异氰酸盐和醇。
• N-Thio-Anthranilamid Compounds and Their Use as Pesticides
  申请人：Schmidt Thomas

  公开号：US20080221168A1

  公开（公告）日：2008-09-11

  N-Thio-anthranilamid compounds of Formula (I) wherein is a group selected from A1 and A2 wherein the variables and the indices are as defined per the description, processes for preparing the compounds (I), pesticidal compositions comprising compounds (I), use of compounds (I) for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of Formula (I).

  公式（I）中的N-硫代蒽酰胺化合物，其中所述的基团选自A1和A2，其中变量和指数如描述中所定义，制备化合物（I）的过程，包含化合物（I）的杀虫剂组合物，使用化合物（I）控制昆虫、螨和线虫，以及使用公式（I）的化合物治疗、控制、预防或保护动物免受寄生虫感染或侵染的方法。
• SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP)
  申请人：Weintraub M. Philip

  公开号：US20070032489A1

  公开（公告）日：2007-02-08

  The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R 1 , R 2 , R 3 and R 4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

  本发明涉及一系列公式I的2,3,5-取代吡啶酮衍生物，其中R，R1，R2，R3和R4如本文所定义。本发明还涉及制备这些化合物的方法。本发明的化合物是聚腺苷酸二磷酸核糖聚合酶（PARP）的抑制剂，因此在治疗和/或预防各种疾病，包括与中枢神经系统和心血管疾病有关的疾病方面，具有药物学上的用途。