2-(Hydroxyimino-methyl)-1-phenethyl-pyridinium; iodide | 78282-80-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Hydroxyimino-methyl)-1-phenethyl-pyridinium; iodide
• 英文别名: N-[[1-(2-phenylethyl)pyridin-1-ium-2-yl]methylidene]hydroxylamine;iodide
• CAS: 78282-80-1
• 化学式: C₁₄H₁₅N₂O*I
• 分子量: 354.19
• InChiKey: SVDMBLFCJZMZHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.97
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  36.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-吡啶甲醛肟 、 2-碘代乙基苯 以 乙醇 为溶剂， 反应 24.0h， 以22%的产率得到2-(Hydroxyimino-methyl)-1-phenethyl-pyridinium; iodide
  参考文献：
  名称：

  De Jong; Benschop; Van Den Berg, European Journal of Medicinal Chemistry, 1981, vol. 16, # 3, p. 257 - 262

  摘要：

  DOI：

文献信息

• 1-Substituted hydroxyiminomethyl-pyridinium salts, with an activity
  申请人：Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijkond

  公开号：US04352810A1

  公开（公告）日：1982-10-05

  1-substituted hydroxyiminomethyl-pyridinium salts, a process for the production of said compounds, compositions with an activity against organophosphate poisonings, and a process for the preparation of such compositions. The invention provides 1-substituted hydroxyiminomethyl-pyridinium salts of the formula 4, wherein R.sub.1 is a substituted or unsubstituted (hetero) aryl group or a corresponding dihydro group, R.sub.2 is a hydrogen, an alkyl or aryl group, R.sub.3 is hydrogen or an alkyl group and Z.sup.- is an anion suited for pharmacological purposes, pharmacological composition containing said compounds and a process for the preparation of said compounds by reacting a pyridine carboxaldoxime with a (hetero) arylhalide. The compounds in question show a good activity against nerve gases and are suited for prophylaxis too.

  1-取代羟亚胺甲基吡啶盐，一种生产上述化合物的方法，具有对抗有机磷中毒活性的组合物，以及制备此类组合物的方法。该发明提供了公式4中R.sub.1为取代或未取代的（杂）芳基或相应的二氢基团，R.sub.2为氢、烷基或芳基团，R.sub.3为氢或烷基团，Z.sup.-为适合药理目的的阴离子的1-取代羟亚胺甲基吡啶盐，含有上述化合物的药理学组合物以及通过将吡啶羧醛肟与（杂）芳基卤化物反应制备上述化合物的方法。所述化合物具有良好的对抗神经毒剂的活性，并且也适用于预防。
• 1-substituted hydroxyiminomethyl-pyridinium salts, a process for the production of said compounds, compositions with an activity against organophosphate poisonings, and a process for the preparation of such compositions
  申请人：Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO

  公开号：EP0023378A1

  公开（公告）日：1981-02-04

  Hydroxyiminomethyl-pyridinium salts of the formula: wherein R, is a substituted or unsubstituted (hetero) aryl group or a corresponding dihydro group, R2 is a hydrogen, an alkyl or aryl group, R, is hydrogen or an alkyl group and Z- is an anion suited for pharmacological purposes, pharmacological composition containing said compounds and a process for the preparation of said compounds by reacting a pyridine carboxaldoxime with a (hetero) arylhalide. The compounds show a good activity against nerve gases and are suited for prophylaxis too.

  式中 R，是取代或未取代的（杂）芳基或相应的二氢基团；R2 是氢、烷基或芳基；R，是氢或烷基；Z- 是适用于药理学目的的阴离子；含有上述化合物的药理组合物；以及通过吡啶羧醛肟与（杂）芳基卤化物反应制备上述化合物的工艺。 这些化合物对神经毒气具有良好的活性，也适用于预防。
• US4352810A
  申请人：——

  公开号：US4352810A

  公开（公告）日：1982-10-05