2-methyl-4-isobutoxy-6-[N-(5-carboxythiazol-2-yl)carbamoyl]benzofurane | 697748-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-methyl-4-isobutoxy-6-[N-(5-carboxythiazol-2-yl)carbamoyl]benzofurane
• 英文别名: 2-methyl-4-isobutoxy-6-[N-(5-carboxythiazol-2-yl)carbamoyl]benzofuran；2-[[2-Methyl-4-(2-methylpropoxy)-1-benzofuran-6-carbonyl]amino]-1,3-thiazole-5-carboxylic acid
• CAS: 697748-10-0
• 化学式: C₁₈H₁₈N₂O₅S
• 分子量: 374.417
• InChiKey: XCDSRKRYNHJWLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] BENZOFURAN DERIVATES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF<br/>[FR] DERIVES DE BENZOFURANNE, LEUR PROCEDE DE PREPARATION ET LEURS INTERMEDIAIRES
  申请人：ASTRAZENECA AB

  公开号：WO2004046139A1

  公开（公告）日：2004-06-03

  Compound of formula (I) wherein A is selected from pyridin-2-yl or thiazol-2-yl and R1, R2 and R3 are as described in the specification and their use in the treatment or prevention of a disease or medical conditions mediated through glucokinase.

  化合物的公式（I），其中A选自吡啶-2-基或噻唑-2-基，R1、R2和R3如规范中描述，并且它们在通过葡萄糖激酶介导的疾病或医疗状况的治疗或预防中的用途。
• Benzofuran derivatives, process for their preparation and intermediates thereof
  申请人：Mckerrecher Darren

  公开号：US20060058353A1

  公开（公告）日：2006-03-16

  Compound of formula (I) wherein A is selected from pyridin-2-yl or thiazol-2-yl and R 1 , R 2 and R 3 are as described in the specification and their use in the treatment or prevention of a disease or medical conditions mediated through glucokinase.

  式(I)的复合物，其中A选自于吡啶-2-基或噻唑-2-基，R1、R2和R3如说明书所述，并且它们在通过葡萄糖激酶介导的疾病或医学状况的治疗或预防中的用途。
• BENZOFURAN DERIVATES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF
  申请人：AstraZeneca AB

  公开号：EP1578745A1

  公开（公告）日：2005-09-28
• BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF
  申请人：AstraZeneca AB

  公开号：EP1578745B1

  公开（公告）日：2007-11-14
• US7709505B2
  申请人：——

  公开号：US7709505B2

  公开（公告）日：2010-05-04