3,4,5-triphenyl-1H-pyrano[4,3-c]quinolin-1-one | 1415835-04-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 3,4,5-triphenyl-1H-pyrano[4,3-c]quinolin-1-one
• CAS: 1415835-04-9
• 化学式: C₃₀H₁₉NO₂
• 分子量: 425.486
• InChiKey: UFFMJJWLSYEGQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.34
• 重原子数：
  33.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3,4,5-triphenyl-1H-pyrano[4,3-c]quinolin-1-one 、 S-(4-叔-丁基苯甲基)[2-(1-甲基丁基)吡啶-3-基]硫代氨基甲酸酯 以 乙醇 为溶剂， 以75%的产率得到4,5,6-triphenylbenzo[h][1, 2, 4]triazolo[3,4a][2, 6]naphthyridin-3(2H)-one
  参考文献：
  名称：

  Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents

  摘要：

  A series of quinoline-based heterocycles prepared and bioevaluated for their possible antimicrobial activity against a panel of gram-positive bacteria [Staphylococcus aureus (ATCC-9144) and Bacillus subtilis (ATCC-6633)] and gram-negative bacteria [Pseudomonas aeruginosa (ATCC-25615), and Escherichia coli (MTCC-739)], and fungal strains [Candida albicans (ATCC-24433), Aspergillus niger (MTCC-872), and Aspergillus fumigatus (MTCC-343)] by the known methods. All the prepared quinoline derivatives have shown significant antimicrobial activities. Few compounds, viz. 4b, 4c and 4a, 4c proved to be active at low concentrations against Sa and Ca, respectively, while compounds 4a, 6d, and 6b showed milder inhibitory effects against other microbes. The structures of newly synthesized compounds were characterized by elemental analysis, Infrared (IR), (HNMR)-H-1, C-13-NMR and Mass-spectroscopy.

  DOI：

  10.1007/s00044-012-0333-2
• 作为产物：
  描述：

  2-苯基-4-喹啉羧酸 、 安息香精油 在 PPA 作用下， 反应 4.0h， 以79%的产率得到3,4,5-triphenyl-1H-pyrano[4,3-c]quinolin-1-one
  参考文献：
  名称：

  Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents

  摘要：

  A series of quinoline-based heterocycles prepared and bioevaluated for their possible antimicrobial activity against a panel of gram-positive bacteria [Staphylococcus aureus (ATCC-9144) and Bacillus subtilis (ATCC-6633)] and gram-negative bacteria [Pseudomonas aeruginosa (ATCC-25615), and Escherichia coli (MTCC-739)], and fungal strains [Candida albicans (ATCC-24433), Aspergillus niger (MTCC-872), and Aspergillus fumigatus (MTCC-343)] by the known methods. All the prepared quinoline derivatives have shown significant antimicrobial activities. Few compounds, viz. 4b, 4c and 4a, 4c proved to be active at low concentrations against Sa and Ca, respectively, while compounds 4a, 6d, and 6b showed milder inhibitory effects against other microbes. The structures of newly synthesized compounds were characterized by elemental analysis, Infrared (IR), (HNMR)-H-1, C-13-NMR and Mass-spectroscopy.

  DOI：

  10.1007/s00044-012-0333-2