2-aminocarbonylamino-6-(benzofuran-2-yl)indole-3-carboxamide | 1040168-25-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-aminocarbonylamino-6-(benzofuran-2-yl)indole-3-carboxamide
• 英文别名: 6-(1-benzofuran-2-yl)-2-(carbamoylamino)-1H-indole-3-carboxamide
• CAS: 1040168-25-9
• 化学式: C₁₈H₁₄N₄O₃
• 分子量: 334.334
• InChiKey: ITBQJQGDCFCWLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• NOVEL INDOLE DERIVATIVE HAVING IKAPPAB KINASE BETA INHIBITORY ACTIVITY
  申请人：Enomoto Hiroshi

  公开号：US20100041628A1

  公开（公告）日：2010-02-18

  Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKKβ and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKKβ. In the formula, R 1 represents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; R 2 represents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like.

  揭示了一种由通式（1）表示的化合物或其盐。该化合物或其盐具有对IKKβ的抑制活性，因此可用作预防和/或治疗与IKKβ相关的疾病的药物。在公式中，R1表示氢原子，低级烷基，芳基，羟基或类似物; R2表示卤素原子，低级烷基，低级烯基，低级炔基或类似物; m表示0，1，2或类似物。
• NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE
  申请人：Santen Pharmaceutical Co., Ltd

  公开号：EP2119703A1

  公开（公告）日：2009-11-18

  Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKKβ and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; R2 represents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like.

  本发明公开了通式（1）所代表的化合物或其盐。该化合物或其盐对 IKKβ 具有抑制活性，因此可用作与 IKKβ 相关疾病的预防和/或治疗剂。式中，R1 代表氢原子、低级烷基、芳基、羟基或类似基团；R2 代表卤素原子、低级烷基、低级烯基、低级炔基或类似基团；m 代表 0、1、2 或类似基团。
• US8193237B2
  申请人：——

  公开号：US8193237B2

  公开（公告）日：2012-06-05