3-(3-氯苯基)-1-(1-甲基-4-氧代-5H-咪唑-2-基)脲水合物 | 63540-28-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(3-氯苯基)-1-(1-甲基-4-氧代-5H-咪唑-2-基)脲水合物
• 英文名称: fenobam monohydrate
• 英文别名: 1-m-Chlorophenyl-3-(1-methyl-4-oxo-2-imidazolidinylidene) urea hydrate；1-(3-Chlorophenyl)-3-(1-methyl-4-oxoimidazolidin-2-ylidene)urea;hydrate
• CAS: 63540-28-3
• 化学式: C₁₁H₁₁ClN₄O₂*H₂O
• 分子量: 284.702
• InChiKey: UNFQKKSADLVQJE-UHFFFAOYSA-N

物化性质

• 溶解度：
  二甲基亚砜：100 mM

计算性质

• 辛醇/水分配系数(LogP)：
  0.46
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  74.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• DELIVERY SYSTEMS FOR IMPROVING ORAL BIOAVAILABILITY OF FENOBAM, ITS HYDRATES, AND SALTS
  申请人：Murty, Santos B.

  公开号：EP2773344A1

  公开（公告）日：2014-09-10
• Delivery Systems For Improving Oral Bioavailability of Fenobam, Its Hydrates, And Salts
  申请人：Murty Santos B.

  公开号：US20130122102A1

  公开（公告）日：2013-05-16

  A delivery system for administration to a patient of Fenobam, its hydrates, and salts optimizes solubility and dissolution properties of Fenobam, its hydrates, and salts using either microemulsions, solid dispersions, cyclodextrin, gastroretentives, enteric coatings, and sustained delivery techniques to provide a vehicle for oral administration of these drugs.
• BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
  申请人：PHARNEXT

  公开号：US20140378440A1

  公开（公告）日：2014-12-25

  The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.
• US3983135A
  申请人：——

  公开号：US3983135A

  公开（公告）日：1976-09-28
• US4025517A
  申请人：——

  公开号：US4025517A

  公开（公告）日：1977-05-24