1,2;,6,8-diepoxy-p-menthane | 5718-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 1,2;,6,8-diepoxy-p-menthane
• 英文别名: 1,2;,6,8-Diepoxy-p-menthan；2,7,7-Trimethyl-3,8-dioxatricyclo[4.2.1.02,4]nonane
• CAS: 5718-71-8
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: WLJXUTHFMCAGKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2;,6,8-diepoxy-p-menthane 、 硫酸 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Wallach, Justus Liebigs Annalen der Chemie, 1896, vol. 291, p. 342

  摘要：

  DOI：
• 作为产物：
  描述：

  1,6-dibromo-p-menthane-2,8-diol 在 sodium methylate 作用下， 生成 1,2;,6,8-diepoxy-p-menthane
  参考文献：
  名称：

  Wallach, Justus Liebigs Annalen der Chemie, 1896, vol. 291, p. 342

  摘要：

  DOI：

文献信息

• Ginsberg, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1898, vol. 30, p. 681
  作者：Ginsberg

  DOI：——

  日期：——
• Wagner; Slawinski, Chemische Berichte, 1899, vol. 32, p. 2069
  作者：Wagner、Slawinski

  DOI：——

  日期：——
• Henderson; Marsh, Journal of the Chemical Society, 1921, vol. 119, p. 1499
  作者：Henderson、Marsh

  DOI：——

  日期：——
• METHOD FOR TREATING AN AUTOIMMUNE NEUROLOGICAL DISEASE AND/OR NEURODEGENERATIVE DISEASE AND PHARMACEUTICAL FORMULATIONS FOR A LIQUID DOSAGE FORM AND A CONTROLLED RELEASE DOSAGE FORM
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20190000776A1

  公开（公告）日：2019-01-03

  A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH 3 or CH 2 , Y is null, O or N, R 1 is H, OH, and R 2 is null, H, C 1 -C 8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO 2 , —NH 2 , —NR 3 R 4 , carbonyl, alkoxyl, alkyl or —OCF 3 , wherein R 3 and R 4 independently are H, alkyl, —SO 2 CH 3 , —(C═O)—CH 3 or —(C═O)—NH 2 .
• MULTI-PARTICULATE PHARMACEUTICAL COMPOSITION, IMMEDIATE RELEASE PELLETS, SUSTAINED RELEASE PELLETS, ENTERIC RELEASE PELLETS AND USE THEREOF
  申请人：Industrial Technology Research Institute

  公开号：US20210290557A1

  公开（公告）日：2021-09-23

  A multi-particulate pharmaceutical composition includes mixture pellets including at least two of the following pellets: a first immediate-release pellet, a sustained-release pellet, an enteric-release pellet and an enteric coated sustained-release pellet.