(2S,5R,6R)-6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | 65272-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (2S,5R,6R)-6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS: 65272-58-4
• 化学式: C36H36ClN5O11S2
• 分子量: 814.3
• InChiKey: TYTFNZHOAWXTDC-QTWNEXLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  55
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  287
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• Large-scale manufacturing process for the production of pharmaceutical compositions
  申请人：Banach Maria

  公开号：US20060073173A1

  公开（公告）日：2006-04-06

  Methods for manufacturing pharmaceutical compositions with a predetermined surface tension or other properties are provided. Also provided are pharmaceutical compositions with a predetermined surface tension or other properties, articles of manufacture containing the pharmaceutical compositions and systems for preparation of the compositions.

  提供了制造具有预定表面张力或其他性质的制药组合物的方法。还提供了具有预定表面张力或其他性质的制药组合物，包含制药组合物的制品以及制备组合物的系统。
• LARGE-SCALE MANUFACTURING PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS
  申请人：Naryx Pharma, Inc.

  公开号：EP1796661A2

  公开（公告）日：2007-06-20
• METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION
  申请人：The Board of Trustees of the University of Alabama

  公开号：EP1951262A2

  公开（公告）日：2008-08-06
• Methods of using small molecule compounds for neuroprotection
  申请人：Caldwell A. Guy

  公开号：US20070203079A1

  公开（公告）日：2007-08-30

  Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.
• Method for detecting anti-vinculin antibodies in a subject with an ibs symptom
  申请人：Cedars-Sinai Medical Center

  公开号：US20180088130A1

  公开（公告）日：2018-03-29

  Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.