di-o-tolylsilanediol | 18407-50-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di-o-tolylsilanediol
• 英文别名: (2-toy)2Si(OH)2；di-o-tolyl-silanediol；Di-o-tolyl-silandiol；Di-o-tolylsilandiol；Dihydroxy-bis(2-methylphenyl)silane
• CAS: 18407-50-6
• 化学式: C₁₄H₁₆O₂Si
• 分子量: 244.365
• InChiKey: HHSNTVIAZSBSSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Di-o-tolyldifluorosilane 以 not given 为溶剂， 以80%的产率得到di-o-tolylsilanediol
  参考文献：
  名称：

  Eaborn, C., Journal of the Chemical Society

  摘要：

  DOI：

文献信息

• Transmission of electronic effects in organosilanols
  作者：Glyn I. Harris

  DOI：10.1039/j29710002083

  日期：——

  The effectiveness of the silicon atom in transmitting electronic effects in a series of substituted diphenylsilanediols, dialkylsilanediols, and poly(diorganosiloxane)-αω-diols has been shown by an i.r. spectroscopy study to be high. The acidities of the diorganosilanediols give an approximately linear correlation with Σσ* values, while the protondonating properties of the substituted diphenylsilanediols

  红外光谱研究表明，硅原子在一系列取代的二苯基硅烷二醇，二烷基硅烷二醇和聚（二有机硅氧烷）-αω-二醇中传递电子效应的有效性很高。所述diorganosilanediols的酸度得到具有Σ的近似线性关系σ *值，而取代diphenylsilanediols的protondonating性能下降的顺序米-CF 3 >米-Cl> p -Cl> p -F> ö -Me>ħ > m -Me> p -Me> p -MeO> p -Me 2 N.根据烷基苯甲酸，二甲苯基硅烷二醇的邻位异构体是最酸性的，这同样归因于空间上的共振抑制。已经根据共振结构的贡献解释了卤代二苯基硅烷二醇的酸度，并与热缩合数据有关。计算了苯酚与聚（二有机硅氧烷）-αω-二醇相互作用的焓值，并根据硅氧烷链中的多中心π键解释了碱度的变化。许多对位取代的二苯基硅烷二醇似乎是双晶的。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 89, page 242 - 246
  作者：

  DOI：——

  日期：——
• Eaborn, C., Journal of the Chemical Society
  作者：Eaborn, C.

  DOI：——

  日期：——
• STERIC HINDRANCE IN HIGHLY-SUBSTITUTED ORGANOSILICON COMPOUNDS. I. THE REACTION OF ARYLLITHIUM COMPOUNDS WITH SOME CHLOROSILANES, ETHOXYSILANES, AND RELATED COMPOUNDS
  作者：HENRY GILMAN、G. N. RUSSELL SMART

  DOI：10.1021/jo01150a003

  日期：1950.7
• Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study
  作者：Maureen J O'Sullivan、Michael Kyriakos、Xiaopei Zhu、Mark R Wick、Paul E Swanson、Louis P Dehner、Paul A Humphrey、John D Pfeifer

  DOI：10.1038/modpathol.3880230

  日期：2000.11

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.