3-Isopropyl-pyridin-1-oxid | 20970-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Isopropyl-pyridin-1-oxid
• 英文别名: 3-Isopropylpyridine 1-oxide；1-oxido-3-propan-2-ylpyridin-1-ium
• CAS: 20970-81-4
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: IJEPPSBEILVOHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  25.5
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Signal Pharmaceuticals, LLC

  公开号：US20150175557A1

  公开（公告）日：2015-06-25

  Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R 1 , and R 2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

  本文提供具有以下结构的二氨基嘧啶化合物： 其中X、L、R1和R2如本文所定义，包含有效量二氨基嘧啶化合物的组合物，以及用于治疗或预防PKC-theta介导的疾病或通过抑制激酶（例如PKC-theta）可治疗或预防的疾病的方法。
• 7-Substituted Purine Derivatives for Immunosuppression
  申请人：Ohlmeyer Michael J.

  公开号：US20080119496A1

  公开（公告）日：2008-05-22

  The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III:

  本发明提供了一种新型嘌呤酮及相关衍生物，用于预防和治疗自身免疫疾病、炎症性疾病、肥大细胞介导的疾病和移植排斥反应。这些化合物的一般化学式为III。
• [EN] PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]INDOLE DERIVATIVES AND METHODS OF USE<br/>[FR] PYRIDO[4,3-B]INDOLE ET DÉRIVÉS DE PYRIDO[3,4-B]INDOLE ET PROCÉDÉS D'UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2011103433A1

  公开（公告）日：2011-08-25

  This disclosure is directed to pyrido[4,3-b]indole and pyrido [3,4-b] indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  本公开涉及吡啶并[4,3-b]吲哚和吡啶[3,4-b]吲哚衍生物。还提供了包含这些化合物的药物组合物，以及使用这些化合物在各种治疗应用中的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经元障碍。
• Compound as WNT Signaling Inhibitor, Composition, and Use Thereof
  申请人：An Songzhou

  公开号：US20150119387A1

  公开（公告）日：2015-04-30

  The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition comprising the compound. Further, the present invention relates to the use of the compound and the method of inhibiting the WNT signal transduction pathways.

  本发明涉及一种具有Formula I结构的化合物作为WNT信号传导途径的抑制剂，以及包含该化合物的组合物。此外，本发明涉及该化合物的使用以及抑制WNT信号传导途径的方法。
• BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20170355714A1

  公开（公告）日：2017-12-14

  The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.

  本申请涉及新型双环化合物，其用于控制动物害虫以及用于其制备的过程和中间体。