3-hydroxy-3-phenyl-butyric acid amide | 24506-18-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxy-3-phenyl-butyric acid amide
• 英文别名: 3-Hydroxy-3-phenyl-buttersaeure-amid；3-Hydroxy-3-phenylbutanamide
• CAS: 24506-18-1
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: YGAMAPANSXDVSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 3-hydroxy-3-phenyl-butyric acid amide
  参考文献：
  名称：

  Applied anatomy of the V-shaped fibular osteomyocutaneous flap in reconstruction of the hindfoot

  摘要：

  To establish the applied anatomy of the V-shaped fibular osteomyocutaneous flap pedicled on the peroneal vessels, cadaver dissections were made in 60 lower limbs and 40 calcanei were examined to sum up the features of calcaneal biomechanics on the stability of the foot and the blood supply of the fibular osteomyocutaneous flap. There were four anastomoses and large communicating branches between the lower segment of the peroneal artery and the anterior and posterior tibial arteries. The flap was well supplied by a retrograde circulation through these anastomoses. A suitable length of pedicle was 20 cm. In the sagittal section of the calcaneus passing through the center of the articular surface for the cuboid bone, the arrangement of the trabeculae formed a triangular zone. The V-shaped flap corresponds nicely with the calculated lines of stress evoked by the weight of the body. The procedure may provide a new method for hindfoot reconstruction. This flap meets the criteria outlined for composite tissue reconstruction of defects of the extremities and biomechanics of the hindfoot, especially for calcaneal and cuboid defects.

  DOI：

  10.1007/s00276-001-0215-7

文献信息

• [EN] PYRIMIDINE DERIVATIVES AS OREXIN RECEPTORS ANTAGONISTS<br/>[FR] DERIVES DE PYRIMIDINE UTILISES EN TANT QU'ANTAGONISTES DE RECEPTEURS D'OREXINE
  申请人：SANOFI AVENTIS

  公开号：WO2005075458A1

  公开（公告）日：2005-08-18

  The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,

  本发明涉及通式（I）的俄利新受体拮抗剂，这些拮抗剂对俄利新I受体具有选择性。其中，Ar代表苯基或含有1-3个相同或不同杂原子或亚甲二氧基苯基的5-或6元杂环的环，这些基团可以选择性地用一个或多个相同或不同的C1.4烷基基团、卤原子、羟基、C1-4烷氧基、三卤甲基基团、NHC1.4烷基、-N(CI-4烷基)2或-NHC(=0)-C1-4烷基基团取代。
• Lithiation of trimethylsilyl substituted acetamide derivatives
  作者：Tina Morwick

  DOI：10.1016/s0040-4039(00)78652-7

  日期：1980.1

  The lithio anions of N,O-bis(trimethylsilyl)acetamide and N-(trimethylsilyl)-N-methylacetamide were prepared and reacted with several carbonyl compounds to form β hydroxy acetamide and N-methylacetamide derivatives.

  制备了N，O-双（三甲基甲硅烷基）乙酰胺和N-（三甲基甲硅烷基）-N-甲基乙酰胺的硫代阴离子，并与几种羰基化合物反应形成β-羟基乙酰胺和N-甲基乙酰胺衍生物。
• Antipicornaviral compounds, compositions containing them, and methods for their use
  申请人：——

  公开号：US20040072907A1

  公开（公告）日：2004-04-15

  A magnetic circuit component having a plurality of claws arranged in a plurality of rows, with the base of each claw connected to a common yoke. A plurality of non-interlaced coils constituting a multi-phase winding are included, with the coils being wound around the bases of corresponding claws, and being distributed uniformly in the direction of motion.

  一种磁路元件，其具有多个爪子，这些爪子排列成多行，每个爪子的底部连接到一个共同的轭上。包括多个非交错线圈的多相绕组，这些线圈绕在相应爪子的底部上，并在运动方向上均匀分布。
• Antipicornaviral compounds and compositons, their pharmaceutical uses, and materials for their synthesis
  申请人：——

  公开号：US20030130204A1

  公开（公告）日：2003-07-10

  Peptido and peptidomimetic compounds of the formula: 1 wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

  肽和肽类似化合物的公式为：1，其中公式变量如披露中所定义，有利地抑制或阻止了小肠病毒3C蛋白酶的生物活性。这些化合物以及含有这些化合物的制药组合物，对于治疗感染一种或多种小肠病毒（如RVP）的患者或宿主是有用的。还提供了制备这些化合物的中间体和合成方法。
• Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
  申请人：Dragovich Scott Peter

  公开号：US20060046966A1

  公开（公告）日：2006-03-02

  Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

  肽和类肽模拟化合物的公式如下：其中公式变量如披露中所定义，有利地抑制或阻断小肠病毒3C蛋白酶的生物活性。这些化合物以及含有这些化合物的药物组合物，对于治疗感染一种或多种小肠病毒（如RVP）的患者或宿主非常有用。还提供了制备这些化合物的中间体和合成方法。