2,2,2-trifluoro-1-(2-(methylthio)pyrimidin-5-yl)ethanol | 1350349-48-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,2,2-trifluoro-1-(2-(methylthio)pyrimidin-5-yl)ethanol
• 英文别名: 5-Pyrimidinemethanol, 2-(methylthio)-alpha-(trifluoromethyl)-；2,2,2-trifluoro-1-(2-methylsulfanylpyrimidin-5-yl)ethanol
• CAS: 1350349-48-2
• 化学式: C₇H₇F₃N₂OS
• 分子量: 224.207
• InChiKey: QWFATODWXSPOLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE
  申请人：Fukuda Yuichi

  公开号：US20130065905A1

  公开（公告）日：2013-03-14

  The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R 6 and R 7 may be the same or different and each represent a hydrogen atom or the like, R 8 , R 9 , R 19 , and R 11 may be the same or different and each represent a hydrogen atom or the like, R 1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R 3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

  本发明提供一种含氮杂环化合物或其在制药上可接受的盐，具有对色氨酸代谢产物吲哚酮的抑制作用，其化学式为(I)：（其中R6和R7可以相同也可以不同，每个代表氢原子或类似物，R8、R9、R10和R11可以相同也可以不同，每个代表氢原子或类似物，R1代表可以用环烷基等取代的较低烷基，R3代表可选择地取代的芳基或可选择地取代的杂环基）。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING KYNURENINE PRODUCTION INHIBITORY ACTIVITY
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2570411A1

  公开（公告）日：2013-03-20

  The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

  本发明提供了一种对犬尿氨酸的产生具有抑制作用的含氮杂环化合物或其药学上可接受的盐，由式（I）表示： 其中 R6 和 R7 可以相同或不同，各自代表氢原子或类似物、 R8、R9、R10 和 R11 可以相同或不同，各自代表氢原子或类似物、 R1 代表可被环烷基或类似物取代的低级烷基，以及 R3 代表任选取代的芳基或任选取代的杂环基团）。
• Nitrogen-containing heterocyclic compound having inhibitory effect on production of kynurenine
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US10548891B2

  公开（公告）日：2020-02-04

  The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R10, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

  本发明提供了一种对犬尿氨酸的产生具有抑制作用的含氮杂环化合物或其药学上可接受的盐，由式（I）表示： （其中 R6 和 R7 可以相同或不同，各自代表氢原子或类似物、 R8、R9、R10 和 R11 可以相同或不同，各自代表氢原子或类似物、 R1 代表可被环烷基或类似物取代的低级烷基，以及 R3 代表任选取代的芳基或任选取代的杂环基团）。
• US9150569B2
  申请人：——

  公开号：US9150569B2

  公开（公告）日：2015-10-06