NSC-203024 | 32349-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: NSC-203024
• 英文别名: N.N'-{1,2-dimethylethylene}thiourea；4,5-dimethylimidazolidine-2-thione；4,5-dimethyl-imidazolidine-2-thione；4,5-Dimethyl-imidazolidin-2-thion；4,5-Dimethylimidazoline-2-thione
• CAS: 32349-16-9
• 化学式: C₅H₁₀N₂S
• 分子量: 130.214
• InChiKey: GYAHKUOFGNDLJV-UHFFFAOYSA-N

物化性质

• 熔点：
  168.5-169 °C
• 沸点：
  168.9±23.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  NSC-203024 生成 4,5-Dimethyl-2-methylthio-2-imidazolin
  参考文献：
  名称：

  HARDTMANN G. E.; KOLETAR G.; PFISTER O. R.; GOGERTY J. H.; IORIO L. C., J. MED. CHEM. , 1975, 18, NO 5, 447-453

  摘要：

  DOI：
• 作为产物：
  描述：

  (2-amino-1-methyl-propyl)-dithiocarbamic acid 在 水 作用下， 生成 NSC-203024
  参考文献：
  名称：

  Zahlova, Collection of Czechoslovak Chemical Communications, 1930, vol. 2, p. 108,110

  摘要：

  DOI：

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Hg: MVol.B4, 1.7.4, page 1333 - 1339
  作者：

  DOI：——

  日期：——
• 5,6-Dihydro-3-(5-nitro-2-furyl)imidazo[2,1-b]thiazoles and Acid Addition Salts¹
  作者：Harry R. Snyder、Louis E. Benjamin

  DOI：10.1021/jm00321a032

  日期：1966.5
• Clinical Characteristics and Six-Month Outcomes of Nursing Home Residents With Low Activities of Daily Living Dependency
  作者：A. Buttar、C. Blaum、B. Fries

  DOI：10.1093/gerona/56.5.m292

  日期：2001.5.1

  Background. Up to 30% of nursing home residents have very little dependency in activities of daily living (ADLs). We compared the characteristics and six-month outcomes of a sample of low-ADL-dependent nursing home residents (LDR) with other residents.Methods. This is a cross-sectional, six-month follow-up study using secondary data analysis. We combined the separate 1990 and 1993 cohorts in the Resident Assessment Instrument evaluation study. In each case these data were collected in the same 254 nursing homes in 10 states. We studied residents with a length of stay greater than 60 days and age 65 years and older (N = 3955). We compared the baseline characteristics of LDR (n = 985) with all other residents. We then compared six-month outcomes of LDR with other residents and characteristics of LDR with poor outcomes (death or worsened ADL disability) with LDR who remained stable.Results. The LDR had a significantly decreased frequency of geriatric syndromes (i.e., cognitive impairment, urinary incontinence, under-nutrition, vision problems, poor balance, and pressure ulcers) and neurological disease but had the same frequency of non-neurological chronic diseases and were on more medications. Thirty-one percent had poor six-month outcomes associated with baseline poor cognition, incontinence, poor appetite, and presence of vascular disease, daily pain, shortness of breath, and multiple medications.Conclusion. Our research identified 29% of nursing home residents with higher physical function (LDR) who had fewer geriatric syndromes and neurological disease diagnoses; 69% of these remained stable at 6 months. Those LDR with a higher risk of poor outcomes could be prospectively identified. LDR who remained stable for 6 months may represent a group who could potentially be maintained in the community.
• Synthesis and structure of some imidazolidine-2-thiones
  作者：T. S. Zhivotova、A. M. Gazaliev、S. D. Fazylov、Z. K. Aitpaeva、D. M. Turdybekov

  DOI：10.1134/s1070428006030183

  日期：2006.3
• Zahlova, L., Collection of Czechoslovak Chemical Communications, 1930, vol. 2, p. 108 - 111
  作者：Zahlova, L.

  DOI：——

  日期：——