2-(Pyridin-4-yl)nicotinaldehyde | 1214326-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(Pyridin-4-yl)nicotinaldehyde
• 英文别名: 2-pyridin-4-ylpyridine-3-carbaldehyde
• CAS: 1214326-12-1
• 化学式: C₁₁H₈N₂O
• 分子量: 184.19
• InChiKey: ZPAUXNZCKNOCIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUNDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20130090341A1

  公开（公告）日：2013-04-11

  The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种化合物，该化合物作为预防或治疗神经退行性疾病等的药剂有用，或者其盐。 本发明涉及一种由下式表示的化合物 其中，每个符号如说明书中所定义， 或其盐。
• METHOD FOR PRODUCING HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20180297980A1

  公开（公告）日：2018-10-18

  The present invention provides a production method of heterocyclic compound having an excellent CH24H inhibitory action, which is suitable for industrial production. In the present invention, a 2-halogenonicotinic acid or a reactive derivative thereof or a salt thereof is reacted with 4-benzyl-4-hydroxypiperidine acid addition salt to give a (4-benzyl-4-hydroxypiperidin-1-yl) (2-halogenopyridin-3-yl)methanone or a salt thereof, and then the obtained compound is reacted with pyridine-4-boronic acid or a reactive derivative thereof or a salt thereof in the presence of a metal catalyst and a base to give (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a salt thereof.

  本发明提供了一种具有优异CH24H抑制作用的杂环化合物的生产方法，适用于工业生产。在本发明中，将2-卤代烟酸或其反应衍生物或其盐与4-苄基-4-羟基哌啶酸盐反应，得到(4-苄基-4-羟基哌啶-1-基)(2-卤代吡啶-3-基)甲酮或其盐，然后将所得化合物与吡啶-4-硼酸或其反应衍生物或其盐在金属催化剂和碱的存在下反应，得到(4-苄基-4-羟基哌啶-1-基)(2,4′-联吡啶-3-基)甲酮或其盐。
• 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20140228373A1

  公开（公告）日：2014-08-14

  The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种化合物及其盐，可用作预防或治疗神经退行性疾病等的药剂。本发明涉及一种由式(I)表示的化合物，其中每个符号如规范中定义的，或其盐。
• 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10144743B2

  公开（公告）日：2018-12-04

  The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种可用于预防或治疗神经退行性疾病等的化合物或其盐。 本发明涉及一种由式表示的化合物 其中各符号如说明书中所定义，或其盐。
• Method for producing heterocyclic compound
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US10562881B2

  公开（公告）日：2020-02-18

  The present invention provides a production method of heterocyclic compound having an excellent CH24H inhibitory action, which is suitable for industrial production. In the present invention, a 2-halogenonicotinic acid or a reactive derivative thereof or a salt thereof is reacted with 4-benzyl-4-hydroxypiperidine acid addition salt to give a (4-benzyl-4-hydroxypiperidin-1-yl) (2-halogenopyridin-3-yl)methanone or a salt thereof, and then the obtained compound is reacted with pyridine-4-boronic acid or a reactive derivative thereof or a salt thereof in the presence of a metal catalyst and a base to give (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a salt thereof.

  本发明提供了一种具有优异的 CH24H 抑制作用的杂环化合物的生产方法，该方法适用于工业生产。 在本发明中，2-卤代烟酸或其活性衍生物或其盐与 4-苄基-4-羟基哌啶酸加成盐反应，得到（4-苄基-4-羟基哌啶-1-基）（2-卤代吡啶-3-基）甲酮或其盐、然后在金属催化剂和碱存在下，将得到的化合物与吡啶-4-硼酸或其活性衍生物或其盐反应，得到（4-苄基-4-羟基哌啶-1-基）（2,4′-联吡啶-3-基）甲酮或其盐。