4-{2-[(Difluoroacetyl)amino]ethyl}-N-isopropyl-7-methyl-3-oxo-N-[(3R)-piperidin-3-yl]-3,4-dihydrospiro[1,4-benzoxazine-2,1'-cyclopropane]-6-carboxamide hydrochloride | 1163280-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-{2-[(Difluoroacetyl)amino]ethyl}-N-isopropyl-7-methyl-3-oxo-N-[(3R)-piperidin-3-yl]-3,4-dihydrospiro[1,4-benzoxazine-2,1'-cyclopropane]-6-carboxamide hydrochloride
• 英文别名: 4-[2-[(2,2-difluoroacetyl)amino]ethyl]-7-methyl-3-oxo-N-[(3R)-piperidin-3-yl]-N-propan-2-ylspiro[1,4-benzoxazine-2,1'-cyclopropane]-6-carboxamide;hydrochloride
• CAS: 1163280-23-6
• 化学式: C₂₄H₃₂F₂N₄O₄*ClH
• 分子量: 515.0
• InChiKey: PHPZZTNOVWKOMH-PKLMIRHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  91
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• BICYCLIC HETEROCYCLIC DERIVATIVE
  申请人：Nakahira Hiroyuki

  公开号：US20110190278A1

  公开（公告）日：2011-08-04

  The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R 1a is halogen, etc.; R 1m is H, etc.; G 1 is —N(R 1b )—, etc.; G 2 is —CO—, etc.; G 3 is —C(R 1c )(R 1d )—, etc.; G 4 is oxygen, etc.; R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are independently the same or different, H, etc.; R 3 is H, optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3 c and R 3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

  本发明涉及以下式（I）的化合物或其药学上可接受的盐，其可用作肾素抑制剂。[其中，R1a是卤素等；R1m是H等；G1是—N（R1b）—等；G2是—CO—等；G3是—C（R1c）（R1d）—等；G4是氧等；R1b是可选取代的C1-6烷基等；R1c和R1d独立选择为H等；R3是H、可选取代的C1-6烷基等；R3a、R3b、R3c和R3d独立选择为相同或不同的基团：-A-B（其中A是单键等，B是H等）等；n为1等。]
• N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE
  申请人：Suetsugu Satoshi

  公开号：US20120122773A1

  公开（公告）日：2012-05-17

  The present invention provides a compound of formula (I): wherein R 1a is optionally substituted C 1-6 alkyl, etc.; R 1m is hydrogen atom, etc.; G 1 , G 2 , G 3 and G 4 are (i), etc. ((i) G 1 is —N(R 1b )—, G 2 is —CO—, G 3 is —C(R 1c )(R 1d )—, and G 4 is oxygen, etc.); R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are each independently optionally substituted C 1-6 alkyl, etc.; R 2 is optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c and R 3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R 5 is C 1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

  本发明提供了一种化合物，其化学式为(I)：其中R1a是可选取代的C1-6烷基等；R1m是氢原子等；G1，G2，G3和G4是(i)等，((i) G1是—N(R1b)—，G2是—CO—，G3是—C(R1c)(R1d)—，G4是氧原子等)；R1b是可选取代的C1-6烷基等；R1c和R1d分别独立地是可选取代的C1-6烷基等；R2是可选取代的C1-6烷基等；R3a、R3b、R3c和R3d分别独立地是一种基团：-A-B（其中A是单键等，B是氢原子等）等；n是1等；R5是C1-4烷氧羰基等，或其药学上可接受的盐，其作为一种肾素抑制剂是有用的。
• US8389511B2
  申请人：——

  公开号：US8389511B2

  公开（公告）日：2013-03-05
• US8658639B2
  申请人：——

  公开号：US8658639B2

  公开（公告）日：2014-02-25