2-Pyridyl-2-(5-methylpyridyl)methan | 29280-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Pyridyl-2-(5-methylpyridyl)methan
• 英文别名: 5-methyl-2,2'-methanediyl-bis-pyridine；5-Methyl-2-(pyridin-2-ylmethyl)pyridine
• CAS: 29280-14-6
• 化学式: C₁₂H₁₂N₂
• 分子量: 184.241
• InChiKey: FPEMYRPZWHHVQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS
  申请人：Portola Pharmaceuticals, Inc.

  公开号：EP3176154A1

  公开（公告）日：2017-06-07

  The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.

  本发明涉及式I化合物及其药学上可接受的盐、酯和原药，它们是Syk激酶的抑制剂。本发明还涉及用于制造此类化合物的中间体、此类化合物的制备方法、含有此类化合物的药物组合物、抑制 Syk 激酶活性的方法、抑制血小板聚集的方法，以及预防或治疗至少部分由 Syk 激酶活性介导的多种疾病（如非霍奇金淋巴瘤）的方法。
• Compounds and compositions for the inhibition of NAMPT
  申请人：Forma TM, LLC

  公开号：US10329275B2

  公开（公告）日：2019-06-25

  The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

  本发明涉及抑制 NAMPT 的化合物和组合物、其合成、应用和解毒剂。本发明的一个实施方案是提供一种式 IIIA 的化合物。
• Compounds and compositions for inhibition of FASN
  申请人：FORMA Therapeutics, Inc.

  公开号：US10399951B2

  公开（公告）日：2019-09-03

  The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.

  本发明涉及抑制 FASN 的化合物和组合物、其合成、应用和解毒剂。
• 6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
  申请人：Sprint Bioscience AB

  公开号：US11179399B2

  公开（公告）日：2021-11-23

  The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

  本发明提供了新颖的式(I)的6-杂环基-4-吗啉-4-基吡啶-2-酮化合物、含有此类化合物的药物组合物以及使用此类化合物治疗包括癌症、糖尿病、炎症性疾病、神经退行性疾病、心血管疾病和病毒感染等疾病的方法；其中R1、R2、R3和A如说明书中所定义。
• Peritoneal therapeutic fluid
  申请人：OPTERION Health AG

  公开号：US11160766B2

  公开（公告）日：2021-11-02

  Peritoneal therapeutic fluid comprising one or more of a biocompatibility enhancing agent (BCA) that is selected from the group consisting of a polyphenolic compound, a metabolite of a polyphenolic compound which is obtained by metabolization in the human or animal body, a salt or a glycoside of a polyphenolic compound.

  含有一种或多种生物相容性增强剂（BCA）的腹膜治疗液，这种生物相容性增强剂选自多酚类化合物、多酚类化合物在人或动物体内代谢产生的代谢产物、多酚类化合物的盐或糖苷组成的组。