(4-((thiophen-2-ylmethyl)-amino)-2-nitro-phenyl)-carbamic acid ethyl ester | 721943-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-((thiophen-2-ylmethyl)-amino)-2-nitro-phenyl)-carbamic acid ethyl ester
• 英文别名: ethyl N-[2-nitro-4-(thiophen-2-ylmethylamino)phenyl]carbamate
• CAS: 721943-23-3
• 化学式: C₁₄H₁₅N₃O₄S
• 分子量: 321.357
• InChiKey: OORBDLSMNKGAJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] 1,2,4-TRIAMINOBENZENE DERIVATIVES USEFUL FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM<br/>[FR] DÉRIVÉS DE 1,2,4-TRIAMINOBENZÈNE UTILES POUR TRAITER DES TROUBLES DU SYSTÈME NERVEUX CENTRAL
  申请人：LUNDBECK & CO AS H

  公开号：WO2004058739A1

  公开（公告）日：2004-07-15

  The present invention concerns 1,2,4-triaminobenzene derivatives of the general formula I or pharmaceutically acceptable salts thereof and the use thereof.

  这项发明涉及通式I的1,2,4-三氨基苯衍生物或其药用可接受的盐以及它们的用途。
• 1,2,4-Triaminobenzene derivatives useful for treating disorders of the central nervous system
  申请人：Rottlander Mario

  公开号：US20060014822A1

  公开（公告）日：2006-01-19

  The present invention concerns 1,2,4-triaminobenzene derivatives of the general formula I or pharmaceutically acceptable salts thereof and the use thereof.

  本发明涉及通式I的1,2,4-三氨基苯衍生物或其药学上可接受的盐以及其用途。
• 1,2,4-TRIAMINOBENZENE DERIVATIVES USEFUL FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM
  申请人：H. LUNDBECK A/S

  公开号：EP1578740B1

  公开（公告）日：2007-03-21
• (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20180127357A1

  公开（公告）日：2018-05-10

  A compound, or pharmaceutically acceptable salt thereof, having a formula I of: wherein R 1 is H or optionally-substituted alkyl; R 2 is optionally-substituted alkyl; R 3 and R 4 are each independently H or optionally-substituted alkyl; R 5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R 6 and R 7 are each independently H, deuterium, optionally-substituted alkyl, or R 6 and R 7 together form a carbocyclic; R 8 is optionally-substituted thiazolyl, optionally-substituted thiophenyl, or substituted phenyl, provided that if R 8 is 4-halophenyl, then R 2 is substituted alkyl or branched alkyl or at least one of R 6 or R 7 is not H; and R 30 , R 31 and R 32 are each independently H, deuterium, halogen, substituted sulfanyl, or optionally-substituted alkoxy.
• US7368472B2
  申请人：——

  公开号：US7368472B2

  公开（公告）日：2008-05-06