| 2618-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 2618-26-0
• 化学式: C20H14I6N2NaO6
• 分子量: 1162.8
• InChiKey: XTLSHMBATRNAOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.47
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  6

制备方法与用途

类别

有毒物品

毒性分级

中毒

急性毒性

静脉-大鼠 LD50: 3800 毫克/公斤; 静脉-小鼠 LD50: 3200 毫克/公斤

可燃性危险特性

可燃; 燃烧产生有毒氮氧化物, 碘化物和氧化钠烟雾

储运特性

通风低温干燥

灭火剂

干粉,泡沫,沙土,二氧化碳, 雾状水

文献信息

• Embolus therapy using insoluble microparticles or vesicles containing contrast agents
  申请人：Toner Luke John

  公开号：US20050265923A1

  公开（公告）日：2005-12-01

  The invention provides a method of embolus therapy comprising administering into the vasculature of a perfused zone of tissue in a human or non-human animal subject a composition comprising particles of a size or formulation selected to generate emboli at a target site within said subject, characterised in that as said particles are used solid water-insoluble particles of a non-radioactive diagnostically effective compound or vesicles encapsulating a non-radioactive diagnostically effective compound or a solution thereof, and in that embolus location is detected by a diagnostic imaging technique.

  本发明提供了一种栓塞疗法的方法，包括将包含颗粒的组合物给药到人体或非人类动物受试者的灌注组织区域的血管中，所述颗粒的大小或制剂被选择以在所述受试者的目标部位产生栓塞，其特征在于，所述颗粒使用的是固态水不溶性的非放射性诊断有效化合物颗粒或封装非放射性诊断有效化合物的囊泡或其溶液，并且栓塞位置是通过诊断成像技术检测的。
• [EN] Novel 7-Dehydrocholesterol Derivatives and Methods Using Same<br/>[FR] NOUVEUX DÉRIVÉS DE 7-DÉSHYDROCHOLESTÉROL ET PROCÉDÉS LES UTILISANT
  申请人：WOMEN & INFANTS HOSPITAL OF RHODE ISLAND

  公开号：WO2015157262A1

  公开（公告）日：2015-10-15

  The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

  本发明在某些方面提供了新颖的7-去氢胆固醇（7DHC）衍生物，这些衍生物在治疗或预防癌症以及治疗或预防受试者中的不受控制的血管生成方面是有用的。在本发明的某些实施例中，受试者是人类。在其他方面，本发明提供了制备本发明化合物的方法，或其盐或溶剂。
• METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES
  申请人：Barnett Bradley Powers

  公开号：US20110104052A1

  公开（公告）日：2011-05-05

  The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.

  本发明提供了一般的组合物，包括水凝胶和药剂，例如治疗剂或成像剂，用于局部区域输送。在本发明的某些优选实施例中，水凝胶组合物可以通过磁共振和CT扫描检测，并用于局部区域输送治疗剂，例如化疗剂。本发明还涉及聚合物基质组合物，包括纳米颗粒，可以在聚合后装载生物活性剂，例如诊断剂或治疗剂。
• Method of preparing liposomes and products produced thereby
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0119020A2

  公开（公告）日：1984-09-19

  A method is provided for preparing a stable liposome precursors in the form of a particulate carrier materials coated with thin films of liposome components, which method includes the steps of dissolving at least one liposome-forming amphipathic lipid, optionally, at least one biologically active compound, and, optionally, at least one adjuvant in a suitable solvent and employing the resulting solution to coat a suitable particulate carrier material which is substantially insoluble in the above-mentioned solvent, to form thin films of liposome components thereon. Upon exposing the coated carrier material to water, the thin films of liposome components hydrate. If the carrier material is water-insoluble, it is then separated e.g. by filtration or centrifuging.

  本发明提供了一种制备稳定的脂质体前体的方法，其形式为涂有脂质体成分薄膜的微粒载体材料，该方法包括以下步骤：将至少一种脂质体形成两性脂质、可选的至少一种生物活性化合物和可选的至少一种佐剂溶解在一种合适的溶剂中，并用所得溶液涂覆在基本上不溶于上述溶剂的合适的微粒载体材料上，以在其上形成脂质体成分薄膜。将涂覆的载体材料置于水中，脂质体成分薄膜就会水合。如果载体材料不溶于水，则通过过滤或离心等方法将其分离。
• X-RAY CONTRAST MEDIUM CONTAINING LIPOSOME AND METHOD FOR PREPARATION THEREOF
  申请人：Konica Minolta Medical & Graphic, Inc.

  公开号：EP1679084A1

  公开（公告）日：2006-07-12

  A radiographic contrast medium is disclosed, comprising liposomes having a narrow vesicle size distribution and comprising a lipid membrane containing a polyalkylene oxide group-containing compound and/or sterols, and the liposomes enclosing a water-soluble nonionic iodine compound. The liposomes which enclose a water phase inside the lipid membrane are dispersed in an aqueous medium, and preferably, both of the water phase and the aqueous medium contain the iodine compound and an additive and each of an iodine compound concentration and an additive concentration is substantially the same in both of the water phase and the aqueous medium, in which the weight ratio of the iodine compound to the lipid membrane is 1 to 10. The contrast medium is prepared by the supercritical carbon dioxide method and therefore, is substantially free of a toxic solvent such as a chlorine-containing solvent.

  本发明公开了一种射线造影剂，它由具有窄囊泡尺寸分布的脂质体组成，脂质体由含有聚环氧烷基化合物和/或甾醇的脂膜组成，脂质体中含有水溶性非离子碘化合物。脂膜内含有水相的脂质体分散在水介质中，最好水相和水介质都含有碘化合物和添加剂，且水相和水介质中碘化合物浓度和添加剂浓度基本相同，其中碘化合物与脂膜的重量比为 1 比 10。对比介质是用超临界二氧化碳法制备的，因此基本上不含有毒溶剂，如含氯溶剂。