4-amino-3-methoxy-N-[2-(1-methylpyrrolidin-2-yl)ethyl]benzamide | 1187094-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-3-methoxy-N-[2-(1-methylpyrrolidin-2-yl)ethyl]benzamide
• CAS: 1187094-60-5
• 化学式: C₁₅H₂₃N₃O₂
• 分子量: 277.367
• InChiKey: MLTOXCHJWJNUMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
  申请人：4SC AG

  公开号：EP2100894A1

  公开（公告）日：2009-09-16

  The invention relates to pyridopyrimidinone compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of Plk1.

  本发明涉及根据式(I)的吡啶并嘧啶酮化合物，其中所述取代基和符号如说明书中所定义。这些化合物是Plk1的抑制剂。
• [EN] PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS<br/>[FR] PYRIDOPYRIMIDINONES COMME INHIBITEURS DE PLK1 (KINASE DE TYPE POLO)
  申请人：4SC AG

  公开号：WO2009112524A1

  公开（公告）日：2009-09-17

  The invention relates to pyridopyrimidinone compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of Plk1.
• [EN] HALO-SUBSTITUTED PYRIMIDODIAZEPINES AS PLKL INHIBITORS<br/>[FR] PYRIMIDODIAZÉPINES À SUBSTITUTION HALOGÉNO EN TANT QU'INHIBITEURS DE PLKL
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009153197A1

  公开（公告）日：2009-12-23

  The present invention provides PLK1 inhibitor compounds of formula (I): useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula (I).