9-hydroxyphenazine-2-carboxylic acid | 99420-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 9-hydroxyphenazine-2-carboxylic acid
• 英文别名: 9-Hydroxy-phenazin-2-carbonsaeure
• CAS: 99420-19-6
• 化学式: C₁₃H₈N₂O₃
• 分子量: 240.218
• InChiKey: ITIIFJOQTOUSKG-UHFFFAOYSA-N

物化性质

• 熔点：
  830 °C (decomp)
• 沸点：
  530.9±25.0 °C(Predicted)
• 密度：
  1.549±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  acetic acid-(8-methyl-phenazin-1-yl ester) 在 chromium(VI) oxide 、 硫酸 、 溶剂黄146 作用下， 生成 9-hydroxyphenazine-2-carboxylic acid
  参考文献：
  名称：

  Kidani, Chemical and pharmaceutical bulletin, 1959, vol. 7, p. 88

  摘要：

  DOI：

文献信息

• Haptenes and Conjugates Derived from Pyocyanin, Antibodies Thereof, and Immunichemical Method for Detecting Infections Caused by Pseudomonas Aeruginosa
  申请人：Marco Colas Maria Pilar

  公开号：US20160033489A1

  公开（公告）日：2016-02-04

  The present invention relates to a compound of general formula I and to the use thereof as a hapten. An object of the present invention is also a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable labelling agent, or with a polymer or support, and to the use thereof for producing antibodies. Furthermore, the present invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

  本发明涉及一种一般式I的化合物以及其作为半抗原的用途。本发明的另一个目的是将所述化合物I与载体蛋白或其片段、可检测标记剂或聚合物或支持物质结合，以及将其用于产生抗体。此外，本发明还涉及一种利用所述抗体和结合物检测和/或定量1-羟基苯并嗪和/或蓝蛋白，用于检测由铜绿假单胞菌引起的感染的方法。
• HAPTENES AND CONJUGATES DERIVED FROM PYOCYANIN, ANTIBODIES THEREOF, AND IMMUNOCHEMICAL METHOD FOR DETECTING INFECTIONS CAUSED BY PSEUDOMONAS AERUGINOSA
  申请人：Consejo Superior De Investigaciones Científicas (CSIC)

  公开号：EP2966066A1

  公开（公告）日：2016-01-13

  The invention relates to a compound of general formula (I) and to the use thereof as a haptene. The invention also relates to a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable marking agent, or with a polymer or support, and to the use thereof for producing antibodies. The invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

  本发明涉及通式 (I) 的化合物及其作为庚烯的用途。 本发明还涉及上述化合物 I 与载体蛋白或其片段、与可检测的标记剂、或与聚合物或支持物的共轭物，以及将其用于生产抗体。本发明还涉及一种使用所述抗体和共轭物检测和/或定量 1-羟基吩嗪和/或焦花青素的方法，用于检测铜绿假单胞菌引起的感染。
• Haptens and conjugates derived from pyocyanin, antibodies thereof, and immunochemical method for detecting infections caused by Pseudomonas aeruginosa
  申请人：Consejo Superior De Investagaciones Cientificas (CSIC)

  公开号：US10422791B2

  公开（公告）日：2019-09-24

  The present invention relates to a compound of general formula I and to the use thereof as a hapten. An object of the present invention is also a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable labelling agent, or with a polymer or support, and to the use thereof for producing antibodies. Furthermore, the present invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

  本发明涉及通式 I 的化合物及其作为合剂的用途。 本发明的另一个目的是将所述化合物 I 与载体蛋白或其片段、可检测的标记剂或聚合物或支持物共轭，并利用其生产抗体。此外，本发明还涉及一种使用所述抗体和共轭物检测和/或定量 1-羟基吩嗪和/或焦花青素的方法，用于检测铜绿假单胞菌引起的感染。
• US4568675A
  申请人：——

  公开号：US4568675A

  公开（公告）日：1986-02-04
• [EN] HAPTENES AND CONJUGATES DERIVED FROM PYOCYANIN, ANTIBODIES THEREOF, AND IMMUNOCHEMICAL METHOD FOR DETECTING INFECTIONS CAUSED BY PSEUDOMONAS AERUGINOSA<br/>[ES] HAPTENOS Y CONJUGADOS DERIVADOS DE PIOCIANINA, ANTICUERPOS DE LOS MISMOS, Y MÉTODO INMUNOQUÍMICO PARA LA DETECCIÓN DE INFECCIONES PROVOCADAS POR PSEUDOMONAS AERUGINOSA<br/>[FR] HAPTÈNES ET CONJUGUÉS DÉRIVÉS DE PYOCYANINE, ANTICORPS DE CEUX-CI, ET PROCÉDÉ IMMUNOCHIMIQUE DE DÉTECTION D'INFECTIONS PROVOQUÉES PAR PSEUDOMONAS AERUGINOSA
  申请人：CONSEJO SUPERIOR INVESTIGACION

  公开号：WO2014135730A1

  公开（公告）日：2014-09-12

  La presente invención se refiere a un compuesto de fórmula general (I) y su uso como hapteno. Es asimismo objeto de la presente invención, un conjugado del compuesto I anterior con una proteína transportadora o fragmento de la misma,con un agente de marcaje detectable, o con un polímero o soporte, así como su uso para la obtención de anticuerpos. Además, la presente invención también hace referencia a un método para la detección y/o cuantificación de 1-hidroxifenazina y/o piocianinaque utiliza los anticuerpos y conjugados anteriorespara la detección de infecciones provocadas por Pseudomonas aeruginosa.