{(R)-7-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl}-carbamic acid phenyl ester | 624729-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: {(R)-7-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl}-carbamic acid phenyl ester
• 英文别名: phenyl-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate；phenyl [(R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate；phenyl N-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate
• CAS: 624729-69-7
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.327
• InChiKey: CKOREQQRNUUBJO-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  {(R)-7-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl}-carbamic acid phenyl ester 、 4-(三氟甲氧基)苯甲胺 以 二甲基亚砜 为溶剂， 反应 1.5h， 以85%的产率得到N-{(R)-7-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl}-N'-(4-trifluoromethoxy-benzyl)-urea
  参考文献：
  名称：

  [EN] HYDROXY TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES
  [FR] DERIVES HYDROXY-TETRAHYDRO-NAPHTALENYLUREE

  摘要：

  这项发明涉及四氢萘衍生物及其盐，可作为药物配方的有效成分。本发明的四氢萘衍生物作为VR1拮抗剂具有出色的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗急迫性尿失禁、过度活跃膀胱、慢性疼痛、神经痛、术后疼痛、类风湿关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、失禁、哮喘和慢性阻塞性肺病等炎症性疾病的治疗。

  公开号：

  WO2003095420A1
• 作为产物：
  描述：

  (R)-8-amino-1,2,3,4-tetrahydronaphthalen-2-ol 、 氯甲酸苯酯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 {(R)-7-Hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl}-carbamic acid phenyl ester
  参考文献：
  名称：

  [EN] HYDROXY TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES
  [FR] DERIVES HYDROXY-TETRAHYDRO-NAPHTALENYLUREE

  摘要：

  这项发明涉及四氢萘衍生物及其盐，可作为药物配方的有效成分。本发明的四氢萘衍生物作为VR1拮抗剂具有出色的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗急迫性尿失禁、过度活跃膀胱、慢性疼痛、神经痛、术后疼痛、类风湿关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、失禁、哮喘和慢性阻塞性肺病等炎症性疾病的治疗。

  公开号：

  WO2003095420A1

文献信息

• [EN] TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES<br/>[FR] DERIVES DE TETRAHYDRO-NAPHTHALENE ET D'UREE
  申请人：BAYER HEALTHCARE AG

  公开号：WO2005040100A1

  公开（公告）日：2005-05-06

  This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD). BHC 03 2 001-Foreign-Countries - 66 - BHC 03 2 001-Foreign-Countries - 65 -

  这项发明涉及四氢萘和脲衍生物及其盐，这些物质可作为药物制剂的活性成分。本发明的四氢萘和脲衍生物具有辣椒素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗与VR1活性相关的泌尿系统疾病或紊乱，如膀胱过度活动（过度活跃膀胱）、尿失禁、神经源性膀胱过度活动（膀胱过度反射）、特发性膀胱过度活动（膀胱不稳定）、良性前列腺增生、下尿路症状；慢性疼痛、神经病性疼痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风，以及哮喘和慢性阻塞性肺病（COPD）等炎症性疾病。BHC 03 2 001-外国国家 - 66 - BHC 03 2 001-外国国家 - 65 -
• Hydroxy tetrahydro-naphthalenylurea derivatives
  申请人：Yura Takeshi

  公开号：US20060258742A1

  公开（公告）日：2006-11-16

  This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence, inflammatory disorders such as asthma and COPD.

  本发明涉及四氢萘衍生物及其盐，该物质可作为药物制剂的活性成分。本发明的四氢萘衍生物具有优良的VR1拮抗剂活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗急迫性尿失禁、过度活动膀胱、慢性疼痛、神经病性疼痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、失禁、哮喘和慢性阻塞性肺病等炎症性疾病。
• Tetradydro-Naphthalene And Urea Derivatives
  申请人：Bouchon Axel

  公开号：US20080045546A1

  公开（公告）日：2008-02-21

  This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

  本发明涉及四氢萘和脲衍生物及其盐，其作为制药制剂的活性成分具有vanilloid受体（VR1）拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗泌尿系统疾病或障碍，如膀胱过度活动（过度活动膀胱），尿失禁，神经源性膀胱过度活动（膀胱过度反射），特发性膀胱过度活动（膀胱不稳定），良性前列腺增生和下尿路症状；慢性疼痛，神经病性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，疼痛，神经损伤，缺血，神经退行性疾病，中风以及哮喘和慢性阻塞性肺（或气道）疾病（COPD）等炎症性疾病。
• Tetrahydro-naphthalene and urea derivatives
  申请人：Bouchon Axel

  公开号：US20070167458A1

  公开（公告）日：2007-07-19

  This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q 1a , Q 2a , Q 3a and Q 4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q 1b , Q 2b , Q 3b , Q 4b , Q 5b , R 1b , na, ma, X a and R a are defined.

  本发明涉及一种羟基四氢萘或脲衍生物公式(I)及其盐，其可用作制药制剂的活性成分，其中A代表公式(II)或(III)，其中#代表连接到分子的位置，Q1a、Q2a、Q3a和Q4a被定义；E代表公式(IV)或(V)，其中#代表连接到分子的位置，Q1b、Q2b、Q3b、Q4b、Q5b、R1b、na、ma、Xa和Ra被定义。
• HYDROXY TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES
  申请人：Bayer HealthCare AG

  公开号：EP1506167B1

  公开（公告）日：2007-08-29