Acetamide, 2-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy]-N-phenyl- | 31191-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Acetamide, 2-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy]-N-phenyl-
• 英文别名: 2-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenoxy]-N-phenylacetamide
• CAS: 31191-19-2
• 化学式: C₁₉H₂₁ClN₆O₂
• 分子量: 400.9
• InChiKey: RVGYMCTZENVEOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• GLYCINE, MITOCHONDRIAL ONE-CARBON METABOLISM, AND CANCER
  申请人：The General Hospital Corporation

  公开号：EP2971153A1

  公开（公告）日：2016-01-20
• Glycine, Mitochondrial One-Carbon Metabolism, and Cancer
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20160032401A1

  公开（公告）日：2016-02-04

  Methods of treatment, diagnosis, and determining prognosis of subjects with cancer, generally comprising determining levels of glycine metabolism or a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2, MTHFD1L, or MTHFD2, and optionally administering an antifolate or an agent that inhibits a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2 or MTHFD2.
• [EN] GLYCINE, MITOCHONDRIAL ONE-CARBON METABOLISM, AND CANCER<br/>[FR] GLYCINE, MÉTABOLISME MITOCHONDRIALE MONOCARBONÉ ET CANCER
  申请人：GEN HOSPITAL CORP

  公开号：WO2014150688A1

  公开（公告）日：2014-09-25

  Methods of treatment, diagnosis, and determining prognosis of subjects with cancer, generally comprising determining levels of glycine metabolism or a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2, MTHFD1L, or MTHFD2, and optionally administering an antifolate or an agent that inhibits a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2 or MTHFD2.