p-Chlorbenzolsulfonylcarbaminsaeure | 34110-78-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Chlorbenzolsulfonylcarbaminsaeure
• 英文别名: (4-Chlorophenyl)sulfonylcarbamic acid
• CAS: 34110-78-6
• 化学式: C₇H₆ClNO₄S
• 分子量: 235.648
• InChiKey: VMPDNFMGDWWNJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ANTI-CANCER TOCOTRIENOL ANALOGUES AND ASSOCIATED METHODS<br/>[FR] ANALOGUES ANTICANCÉREUX DU TOCOTRIÉNOL ET PROCÉDÉS ASSOCIÉS
  申请人：FIRST TECH INTERNAT LTD

  公开号：WO2010124223A1

  公开（公告）日：2010-10-28

  Compounds are disclosed relating to the treatment of cancer that include tocotrienols and derivatives of tocotrienols including 2,5,7,8-tetramethyl-2- ((3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trienyl)chroman-6- ylphenylsulfonylcarbamate; (R)-2,8-dimethyl-2-((3E,7E)-4,8,12-trimethyltrideca- 3,7,1 l-trienyl)chroman-6-yl tosylcarbamate; and (R)-2,5,7,8-tetramethyl-2- ((3E,7E)-4,8, 12-trimethyltrideca-3,7, 1 l-trienyl)chroman-6-yl benzylcarbamate. Therapeutic uses of these types of compounds are also taught.

  披露了涉及癌症治疗的化合物，包括生育三烯酚及其衍生物，包括2,5,7,8-四甲基-2-((3E,7E)-4,8,12-三甲基十三碳烯-3,7,11-三烯基)色苷-6-基苯磺酰氨基甲酸酯；(R)-2,8-二甲基-2-((3E,7E)-4,8,12-三甲基十三碳烯-3,7,11-三烯基)色苷-6-基对甲苯磺酰氨基甲酸酯；以及(R)-2,5,7,8-四甲基-2-((3E,7E)-4,8,12-三甲基十三碳烯-3,7,11-三烯基)色苷-6-基苄基氨基甲酸酯。这些类型化合物的治疗用途也得到了教导。
• [EN] ACYLSUFONAMIDE COMPOUNDS USEFUL AS EP3 RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS D'ACYLSUFONAMIDE UTILES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR EP3
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2020008317A1

  公开（公告）日：2020-01-09

  The present invention is directed to acylsulfonamide derivatives of formula (I), pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of, for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.

  本发明涉及式(I)的酰磺酰胺衍生物，含有它们的药物组合物以及它们作为EP3受体拮抗剂的用途，用于治疗例如口服葡萄糖耐量受损、空腹血糖升高、2型糖尿病、X综合征（也称为代谢综合征）及相关疾病和并发症。
• Imidazole compounds as anti-inflammatory and analgesic agents
  申请人：——

  公开号：US20030220372A1

  公开（公告）日：2003-11-27

  This invention provides a compound of the formula (I): 1 wherein: R 1 represents a hydrogen atom, an alkyl group, etc.; R 2 represents a hydrogen atom, a halogen atom, etc.; R 3 represents a hydrogen atom, an alkyl group, etc.; R 4 represents an aryl group, etc.; A represents an aryl 1 , etc; B represents an alkylene etc.; X represents NH, etc.; or a pharmaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglamndin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.

  这项发明提供了化合物的结构式(I)： 其中： R1代表氢原子、烷基等； R2代表氢原子、卤原子等； R3代表氢原子、烷基等； R4代表芳基等； A代表芳基1等； B代表烷基等； X代表NH等； 或者该化合物的药学上可接受的酯，及其药学上可接受的盐。这些化合物可用于治疗由前列腺素介导的医疗状况，如疼痛、发热或炎症等。该发明还提供了包含上述化合物的药物组合物。
• CANNABINOID RECEPTOR MEDIATING COMPOUNDS
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20160257654A1

  公开（公告）日：2016-09-08

  A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB 1 receptor mediating scaffold and (ii) a second therapeutic scaffold.

  一种化合物，或其药学上可接受的盐或酯，包括（i）CB1受体介导的支架和（ii）第二个治疗支架。
• Carbamates of rapamycin
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0509795A2

  公开（公告）日：1992-10-21

  The invention concerns a compound of the structure: wherein Rl and R2 are each, independently, hydrogen, -CONH(CR3R4)n-X or CONHSO2-Ar; R3 and R4 are each independently, hydrogen, alkyl, aralkyl, cycloalkyl of 3-8 carbon atoms, halogen, or trifluoromethyl; providing that when more than one R3 or R4 group is present then they may be the same or different; X is hydrogen, lower alkyl, cycloalkyl, trifluoromethyl, nitro, alkoxy, carboalkoxy, aralkyl, halo, dialkylamino, thioalkyl, or Y; Y is a phenyl group which may be optionally mono-, di-, or tri- substituted; Ar is phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, quinoxalyl, thienyl, thionaphthyl, furyl, benzofuryl, benzodioxyl, benzoxazolyl, benzoisoxazolyl, or benzodioxolyl; wherein the Ar group may be optionally mono-, di-, or tri-subsrituted, and n = 0-5; with the proviso that R1 and R2 are not both hydrogen and when n = 0, X is lower alkyl, cycloalkyl , aralkyl, or Y; or a pharmaceutically acceptable salt thereof when X is dialkylamino, when the Ar group contains a basic nitrogen, or when the Ar group is substituted by dialklyamino, SO3H, -PO3H, or -CO2H, which by virtue of its immunosuppressive activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases and discases of inflammation; by virtue of its antitumor activity is useful in treating solid tumors; and by virtue of its antifungal activity is useful in treating fungal infections.

  本发明涉及一种结构如下的化合物： 其中Rl和R2各自独立地为氢、-CONH(CR3R4)n-X或CONHSO2-Ar；R3和R4各自独立地为氢、烷基、芳烷基、3-8个碳原子的环烷基、卤素或三氟甲基；当存在一个以上的R3或R4基团时，它们可以相同或不同；X为氢、低级烷基、环烷基、三氟甲基、硝基、烷氧基、羧基、芳烷基、卤素、二烷基氨基、硫代烷基或Y；Ar 是苯基、萘基、吡啶基、喹啉基、异喹啉基、喹喔啉基、噻吩基、硫萘基、呋喃基、苯并呋喃基、苯并二噁基、苯并噁唑基、苯并异噁唑基或苯并二噁唑基；其中 Ar 基团可任选被单取代、二取代或三取代，且 n = 0-5； 但 R1 和 R2 不能都是氢，当 n = 0 时，X 为低级烷基、环烷基、芳烷基或 Y； 或其药学上可接受的盐，当 X 为二烷基氨基时，当 Ar 基团含有碱基氮时，或当 Ar 基团被二烷基氨基、SO3H、-PO3H 或 -CO2H 取代时，由于其免疫抑制活性，可用于治疗移植排斥反应、宿主与移植物疾病、自身免疫性疾病和炎症疾病；由于其抗肿瘤活性，可用于治疗实体瘤；由于其抗真菌活性，可用于治疗真菌感染。