(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dien-1-ol | 872615-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dien-1-ol
• CAS: 872615-39-9
• 化学式: C₃₇H₅₀O₃Si
• 分子量: 570.888
• InChiKey: COQQAYAURBLGBO-FFSIJPEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  41.0
• 可旋转键数：
  15.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dien-1-ol 在 2,6-二叔丁基-4-甲基苯酚 、 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 、 邻二氯苯 、 甲苯 为溶剂， 生成 (1R,2R,3R,3aS,4S,5S,7aR)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-diethyl-1-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-5-carboxylic acid methyl ester
  参考文献：
  名称：

  Toward a Total Synthesis of the Novel Polyketide Natural Product Spiculoic Acid A

  摘要：

  [GRAPHIC]An enantioselective approach toward the recently isolated marine natural product, spiculoic acid A, conceptualized along the proposed biogenetic hypothesis, involving an intramolecular Diels-Alder reaction as the pivotal step, is delineated. Access to a structurally embellished bicyclic core of the natural product has been accomplished.

  DOI：

  10.1021/ol0521329
• 作为产物：
  描述：

  (E)-(2S,3R,4R)-3-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-4-ethyl-2-methyl-oct-5-enal 在 二异丁基氢化铝 作用下， 以 苯 为溶剂， 生成 (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dien-1-ol
  参考文献：
  名称：

  Toward a Total Synthesis of the Novel Polyketide Natural Product Spiculoic Acid A

  摘要：

  [GRAPHIC]An enantioselective approach toward the recently isolated marine natural product, spiculoic acid A, conceptualized along the proposed biogenetic hypothesis, involving an intramolecular Diels-Alder reaction as the pivotal step, is delineated. Access to a structurally embellished bicyclic core of the natural product has been accomplished.

  DOI：

  10.1021/ol0521329