| 1260526-31-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1260526-31-5
• 化学式: C₁₉H₁₇BrN₂O₂
• 分子量: 385.26
• InChiKey: IDDSAKZHAXZYCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  58.2
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  环丙胺 、 4-(4-bromobenzylidene)-2-phenyl-5(4H)oxazolone 以 乙二醇 为溶剂， 反应 0.2h， 以70%的产率得到
  参考文献：
  名称：

  Facile Diversity-Oriented Synthesis of Novel Dipeptide Mimetic Compounds Containing Bioactive Molecular Skeletons under Microwave Irradiation

  摘要：

  The diversity-oriented synthesis of dipeptide mimetic compounds embedded with bioactive molecular skeletons have been successfully established via microwave-assisted reactions between various 4-arylidene-2-phenyloxazol-5(4H)-ones and a broad scope of amines including aliphatic, aromatic, and heteroaromatic ones. This synthetic approach has prominent features of short reaction time, high yields, operational simplicity,as well as widespread applications, leading to a facile and straightforward access to structurally diverse dipeptide analogues with, potential bioactivities, Moreover, the preliminary evaluation on the cytotoxic activity of this type-of dipeptide derivatives has resulted in the finding of five Compounds with stronger cytotoxicity than doxorubicin hydrochloride at the concentration of 10 mu g/mL.

  DOI：

  10.1021/co1000458