5-Pentyl-benzofuran | 331834-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 5-Pentyl-benzofuran
• 英文别名: 5-Pentyl-1-benzofuran
• CAS: 331834-07-2
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: CPJOBNNCZGBCMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Pentyl-benzofuran 在 正丁基锂 、 硼酸三甲酯 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 生成 (5-pentyl-1-benzofuran-2-yl)boronic acid
  参考文献：
  名称：

  摘要：

  The synthesis and transition temperatures are reported for several 2-(4-alkyl- and 4-alkoxy-phenyl)-5-cyano-1-benzofurans, 2-(4'-alkylbiphenyl-4-yl)-5-cyano- and 5-(4'-alkylbiphenyl-4-yl)-2-cyano-1-benzofurans, and for compounds with other combinations of terminal alkyl and cyano groups in 2,5-disubstituted-1-benzofurans containing two phenyl units; some isolated examples of related cyclohexane systems are also presented. The mesogenic behaviour of these compounds and several intermediates (e.g. amides, acids and esters) is discussed and the transition temperatures are rationalised on the following basis (a) 1-benzofuran is a superior core unit to benzene, (b) 2,5-disubstitution in 1-benzofuran gives a bent core which adversely affects mesogenicity, to an extent which depends on its position in the core, (c) antiparallel associations in terminal cyano compounds can eliminate the disadvantage of a bent core structure, (d) 2-aryl-1-benzofurans have negligible inter-annular twist but 5-aryl-1-benzofurans have similar inter-annular twist to that in biphenyls.

  DOI：

  10.1039/b102837p
• 作为产物：
  描述：

  4-戊基苯酚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 10.0h， 生成 5-Pentyl-benzofuran
  参考文献：
  名称：

  可见光诱导的杂芳烃与溴氟乙酸乙酯的单氟亚甲基化

  摘要：

  已经开发了一种通过可见光光催化将乙氧基羰基单氟甲基基团直接引入杂芳烃的温和方法。

  DOI：

  10.1039/c6nj00281a

文献信息

• Bromodifluoromethylation of heteroaromatics with sodium bromodifluoromethanesulfinate
  作者：Jin Zhang、Xiu-Hua Xu、Feng-Ling Qing

  DOI：10.1016/j.tetlet.2016.04.095

  日期：2016.6

  The bromodifluoromethylation of heteroaromatics (benzofuran, benzo[b]thiophene, and 2H-chromen-2-one) with sodium bromodifluoromethanesulfinate (BrCF2SO2Na) was developed. This reaction proceeded smoothly at room temperature to afford the bromodifluoromethylated products in moderate to high yields.

  开发了用溴代二氟甲烷亚磺酸钠（BrCF 2 SO 2 Na）进行杂芳族化合物（苯并呋喃，苯并[ b ]噻吩和2 H-铬-2--2-酮）的溴二氟甲基化。该反应在室温下顺利进行，以中等至高收率得到溴二氟甲基化产物。
• BACTERIAL EFFLUX PUMP INHIBITORS FOR THE TREATMENT OF OPHTHALMIC AND OTIC INFECTIONS
  申请人：Bostian Keith

  公开号：US20080132457A1

  公开（公告）日：2008-06-05

  Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear).

  流出泵抑制剂与抗微生物药物一起联合使用，用于治疗眼科或耳科感染。这些药物可以直接共同应用于感染部位（例如眼睛或耳朵）。
• SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1847533A1

  公开（公告）日：2007-10-24

  A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH2 and the like; RO1 to RO4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents -CH(OH)- group and the like; and W represent -U1-(RW1)(RW2)-U2-U3 group (U1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; RW1 and RW2 represent hydrogen atom and the like; U2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

  通式 (I) 所代表的化合物或其盐： [T 代表氧原子等；V 代表 CH2 等；RO1 至 RO4 代表氢原子等；A 代表具有 2 至 8 个碳原子的直链烯基或直链烯基等；D 代表羧基等；X 代表乙烯基、三亚甲基等；E 代表-CH(OH)- 基等；W 代表-U1-(RW1)(RW2)-U2-U3 基（U1 代表单键、具有 1 至 4 个碳原子的亚烷基等）；RW1 和 RW2 代表氢原子等；U2 代表单键、具有 1 至 4 个碳原子的亚烷基等；U3 代表具有 1 至 8 个碳原子的烷基等），或碳环或杂环化合物的残基]，可用作有效预防和/或治疗骨质疏松症和骨折等骨骼疾病、青光眼、溃疡性结肠炎等疾病的药物的活性成分。
• LIQUID CRYSTAL COMPOUNDS
  申请人：Qinetiq Limited

  公开号：EP1214306A1

  公开（公告）日：2002-06-19
• US7947741B2
  申请人：——

  公开号：US7947741B2

  公开（公告）日：2011-05-24