1-iodo-2,3,5-trifluorobenzene | 622379-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-iodo-2,3,5-trifluorobenzene
• 英文别名: 2,3,5-Trifluoroiodobenzene；1,2,5-trifluoro-3-iodobenzene
• CAS: 622379-51-5
• 化学式: C₆H₂F₃I
• 分子量: 257.982
• InChiKey: GPBVAOZYTPLSLQ-UHFFFAOYSA-N

物化性质

• 沸点：
  179.0±35.0 °C(Predicted)
• 密度：
  2.078±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Method for producing tetrakis ( fluoroaryl) borate-magnesium compound
  申请人：——

  公开号：US20030216598A1

  公开（公告）日：2003-11-20

  Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

  氟芳基镁卤化物与硼化合物反应，使得氟芳基镁卤化物与硼化合物的摩尔比不低于3.0且不高于3.7，从而产生四氟芳基硼酸盐·镁化合物。通过这种方法，不会产生腐蚀生产设备并需要繁琐废水处理的氢氟酸。
• Method for producing fluoroaryl metal compound
  申请人：——

  公开号：US20020065426A1

  公开（公告）日：2002-05-30

  A method for easily and inexpensively producing and purifying a fluoroaryl metal compound such as bis(pentafluorophenyl)dialkyltin which is less colored and has no impurities is provided. Hydrocarbon magnesium halide is reacted with fluoroaryl halide in a solvent including an ether solvent so as to obtain fluoroaryl magnesium halide, which is then reacted with an organic metal compound so as to produce a fluoroaryl metal compound. Tin is more preferable as a metal atom included in the organic metal compound. As for the ether solvent, chain ether solvents are preferable, more specifically, diisopropyl ether, dibutyl ether, and t-butylmethyl ether are more preferable. Besides, it is preferable that magnesium halide, which is a by-product of the fluoroaryl metal compound, is precipitated and removed, or treated with an acid.

  提供了一种简单、廉价的方法来生产和纯化氟芳基金属化合物，例如双(五氟苯基)二烷基锡，该化合物颜色较浅且没有杂质。将碳氢化合物镁卤化物与氟芳基卤化物在包括醚类溶剂的溶剂中反应，以获得氟芳基镁卤化物，然后将其与有机金属化合物反应，以产生氟芳基金属化合物。锡是有机金属化合物中包含的金属原子更为理想。对于醚类溶剂，链醚类溶剂更为理想，更具体地说，二异丙基醚、二丁基醚和叔丁基甲基醚更为理想。此外，最好将氟芳基金属化合物的副产物镁卤化物沉淀并去除，或者用酸处理。
• Method for manufacturing fluoroaryl magnesium halide
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP0995753A2

  公开（公告）日：2000-04-26

  In order to provide a method of safely, efficiently, and industrially manufacturing fluoroaryl magnesium halide containing no impurities, such as coloring components, by a relatively gradual reaction compared with the conventional reactions, and a method of readily and efficiently manufacturing a highly-pure fluoroaryl borane derivative, fluoroaryl magnesium halide expressed by General Formula (1): where each of R1-R5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at least three of R1-R5 are fluorine atoms, and Xa represents Cl, Br, or I; is manufactured by reacting, in a solvent containing a chain ether solvent, hydrocarbon magnesium halide expressed by General Formula (2):         R6MgXa     (2) where R6 represents a hydrocarbon group, and Xa represents Cl, Br, or I; with fluoroaryl halide expressed by General Formula (3): where each of R1-R5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at least three of R1-R5 are fluorine atoms and Xb represents Br or I.

  为了提供一种与传统反应相比通过相对渐进的反应安全、高效、工业化地制造不含着色成分等杂质的氟芳基卤化镁的方法，以及一种容易、高效地制造通式（1）表示的高纯度氟芳基硼烷衍生物--氟芳基卤化镁的方法： 其中每个 R1-R5 独立地代表 H、F、烃基或烷氧基，条件是 R1-R5 中至少有三个是氟原子，Xa 代表 Cl、Br 或 I； 由通式（2）表示的烃卤化镁在含有链醚溶剂的溶剂中反应制得： R6MgXa (2) 其中 R6 代表烃基，Xa 代表 Cl、Br 或 I； 通式（3）表示的氟芳基卤化物： 其中 R1-R5 各独立地代表 H、F、烃基或烷氧基，条件是 R1-R5 中至少有三个是氟原子，且 Xb 代表 Br 或 I。
• Method for producing tetrakis (fluoroaryl) borate magnesium compound
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1362860A1

  公开（公告）日：2003-11-19

  Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

  氟芳基卤化镁与硼化合物反应，使氟芳基卤化镁与硼化合物的摩尔比不小于 3.0 也不大于 3.7，从而生成四（氟芳基）硼酸镁化合物。采用这种方法不会产生氟化氢，而氟化氢会腐蚀生产设备，并需要进行麻烦的废水处理。
• Tricyclic derivatives and their pharmaceutical use and compositions
  申请人：CEPHALON, INC.

  公开号：EP2792678A1

  公开（公告）日：2014-10-22

  This application relates to tricyclic compounds of Formula I: including all stereoisomeric forms, all mixtures of stereoisomeric forms, and salts of these compounds. This application also relates to compositions comprising compounds of Formula I, stereoisomeric forms, all mixtures of stereoisomeric forms, and salts thereof and uses therefor.

  本申请涉及式 I 的三环化合物： 包括所有立体异构体形式、立体异构体形式的所有混合物以及这些化合物的盐。本申请还涉及由式 I 化合物、立体异构体、立体异构体的所有混合物及其盐组成的组合物及其用途。