1-(3-amino-6-methyl-thieno[2,3-b]pyridin-2-yl)-ethanone | 52505-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 1-(3-amino-6-methyl-thieno[2,3-b]pyridin-2-yl)-ethanone
• 英文别名: 3-Amino-2-acetyl-6-methyl-thieno<2,3-b>pyridin；1-(3-Amino-6-methylthieno[2,3-b]pyridin-2-yl)ethanone
• CAS: 52505-52-9
• 化学式: C₁₀H₁₀N₂OS
• 分子量: 206.268
• InChiKey: UAMHDZRSCSBZPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3-amino-6-methyl-thieno[2,3-b]pyridin-2-yl)-ethanone 、 羟胺 生成 (NE)-N-[1-(3-amino-6-methylthieno[2,3-b]pyridin-2-yl)ethylidene]hydroxylamine
  参考文献：
  名称：

  YOUSSEFYEH, R. D.;BROWN, R. E.;WILSON, J.;SHAH, URESH;JONES, H.;LOEV, B.;+, J. MED. CHEM., 1984, 27, N 12, 1639-1643

  摘要：

  DOI：
• 作为产物：
  描述：

  3-Amino-2-acetyl-6-methyl-thieno<2,3-b>pyridin-4-carbonsaeure 生成 1-(3-amino-6-methyl-thieno[2,3-b]pyridin-2-yl)-ethanone
  参考文献：
  名称：

  TORNETTA B.; GUERRERA F.; RONSISVALLE G., ANN. CHIM. (ITAL.), 1974, 64, NO 11-12, 833-842

  摘要：

  DOI：

文献信息

• [EN] CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS<br/>[FR] CARBOXAMIDES UTILISÉES EN TANT QU'INHIBITEURS DE PROTÉASE SPÉCIFIQUE DE L'UBIQUITINE
  申请人：FORMA THERAPEUTICS INC

  公开号：WO2019032863A1

  公开（公告）日：2019-02-14

  The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

  本公开涉及调节剂，如抑制剂，至少选择自USP28和USP25中的一条途径的药物组合物包括这些抑制剂，以及使用这些抑制剂的方法。这些调节剂，如抑制剂，至少选择自USP28和USP25中的一条途径，可用于治疗癌症等疾病。
• Pyrido[3',2':4,5]thieno[3,2-d]-N-triazines: a new series of orally active antiallergic agents
  作者：Raymond D. Youssefyeh、Richard E. Brown、Jeffrey Wilson、Uresh Shah、Howard Jones、Bernard Loev、Atul Khandwala、Mitchell J. Leibowitz、Paula Sonnino-Goldman

  DOI：10.1021/jm00378a019

  日期：1984.12

  A new series of orally active mediator release inhibitors, pyrido[3',2':4,5]thieno[3,2-d]-N-triazines, was synthesized and evaluated for antiallergic activity. Several products showed high activity as inhibitors or wheal information in the rat passive cutaneous anaphylaxis screen and as inhibitors of histamine release from passively sensitized rat mast cells. Many compounds were orally active in the

  合成了一系列新的口服活性介质释放抑制剂，吡啶并[3'，2'：4,5]噻吩并[3,2-d] -N-三嗪，并评估了其抗过敏活性。几种产品在大鼠被动性皮肤过敏反应筛查中表现出较高的抑制剂或通气信息活性，并在被动致敏的大鼠肥大细胞中释放出组胺抑制剂。在PCA测试中，许多化合物具有口服活性。最有效的化合物7-苯基吡啶基-[3'，2'：4,5]噻吩并[3,2-d] -1,2,3-三嗪-4（3H）-I50值为一（10）在RMC分析中，其浓度为0.05 microM，比色甘酸二钠（DSCG）强60倍。
• Ho, Yuh Wen; Wang, Ing Jing, Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 819 - 826
  作者：Ho, Yuh Wen、Wang, Ing Jing

  DOI：——

  日期：——
• Compounds that Inhibit HIV Particle Formation
  申请人：Rekosh David

  公开号：US20110152301A1

  公开（公告）日：2011-06-23

  The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and compounds for inhibiting HIV particle formation and or treating patients infected with HIV.
• [EN] CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS<br/>[FR] CARBOXAMIDES EN TANT QU'INHIBITEURS DE PROTÉASE SPÉCIFIQUES DE L'UBIQUITINE
  申请人：FORMA THERAPEUTICS INC

  公开号：WO2020033707A1

  公开（公告）日：2020-02-13

  The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.